{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:ucin1352484816"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:ucin1352484816","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"Comparison of DNA adducts in mouse bladder and lung tissue from smoke-exposed and control mice","abstract":"Smoking cigarettes is a common exposure pathway that has been linked with various types of cancer, including cancers of the lung and bladder. Carcinogens in the cigarette smoke may lead to the formation of DNA adducts within body tissues. DNA adducts arise from the covalent bond formed between a carcinogenic chemical and DNA. An increase in the number of DNA adducts present in a tissue could indicate the initiation of the carcinogenesis process. The measurement of the number and type of DNA adducts present in a tissue can be used to monitor exposure to a carcinogenic chemical and the dose received. Lungs receive direct exposure to cigarette smoke chemicals and carcinogens, while bladder tissue receives an indirect exposure. The transport of the chemicals and carcinogens throughout the body may decrease the exposure that the bladder receives in comparison with that of the lung. Comparison of the relative adduct levels in both mouse bladder and lung tissue from cigarette smoke-exposed and control mice will provide an indication of the correlation between the levels in each tissue.","abstract_html":"Smoking cigarettes is a common exposure pathway that has been linked with various types of cancer, including cancers of the lung and bladder. Carcinogens in the cigarette smoke may lead to the formation of DNA adducts within body tissues. DNA adducts arise from the covalent bond formed between a carcinogenic chemical and DNA. An increase in the number of DNA adducts present in a tissue could indicate the initiation of the carcinogenesis process. The measurement of the number and type of DNA adducts present in a tissue can be used to monitor exposure to a carcinogenic chemical and the dose received. Lungs receive direct exposure to cigarette smoke chemicals and carcinogens, while bladder tissue receives an indirect exposure. The transport of the chemicals and carcinogens throughout the body may decrease the exposure that the bladder receives in comparison with that of the lung. Comparison of the relative adduct levels in both mouse bladder and lung tissue from cigarette smoke-exposed and control mice will provide an indication of the correlation between the levels in each tissue.","abstract_has_math":false,"creators":["Eastlake, Adrienne C."],"institution":"University of Cincinnati","degree_name":"MS","degree_level":"masters","degree_discipline":"Medicine: Industrial Hygiene (Environmental Health)","degree_department":null,"school":null,"contributors":["Talaska, Glenn"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-24T03:36:23Z","subjects":["Environmental Health","DNA adducts","smoking","lung cancer","bladder cancer"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352484816","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Talaska, Glenn"]},{"key":"dc:creator","label":"Author","values":["Eastlake, Adrienne C."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2012"]},{"key":"dc:publisher","label":"Institution","values":["University of Cincinnati / OhioLINK"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medicine: Industrial Hygiene (Environmental Health)"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["MS"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Cincinnati"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Environmental Health","DNA adducts","smoking","lung cancer","bladder cancer"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. 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Lungs receive direct exposure to cigarette smoke chemicals and carcinogens, while bladder tissue receives an indirect exposure. The transport of the chemicals and carcinogens throughout the body may decrease the exposure that the bladder receives in comparison with that of the lung. Comparison of the relative adduct levels in both mouse bladder and lung tissue from cigarette smoke-exposed and control mice will provide an indication of the correlation between the levels in each tissue."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","p.47","1.58 MB"]},{"key":"dc:title","label":"Title","values":["Comparison of DNA adducts in mouse bladder and lung tissue from smoke-exposed and control mice"]}]}],"canonical_facts":{"dc:contributor":["Talaska, Glenn"],"dc:creator":["Eastlake, Adrienne C."],"dc:date":["2012"],"dc:description":["Smoking cigarettes is a common exposure pathway that has been linked with various types of cancer, including cancers of the lung and bladder. Carcinogens in the cigarette smoke may lead to the formation of DNA adducts within body tissues. DNA adducts arise from the covalent bond formed between a carcinogenic chemical and DNA. An increase in the number of DNA adducts present in a tissue could indicate the initiation of the carcinogenesis process. The measurement of the number and type of DNA adducts present in a tissue can be used to monitor exposure to a carcinogenic chemical and the dose received. Lungs receive direct exposure to cigarette smoke chemicals and carcinogens, while bladder tissue receives an indirect exposure. The transport of the chemicals and carcinogens throughout the body may decrease the exposure that the bladder receives in comparison with that of the lung. Comparison of the relative adduct levels in both mouse bladder and lung tissue from cigarette smoke-exposed and control mice will provide an indication of the correlation between the levels in each tissue."],"dc:format":["application/pdf","p.47","1.58 MB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352484816"],"dc:language":["English"],"dc:publisher":["University of Cincinnati / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"dc:subject":["Environmental Health","DNA adducts","smoking","lung cancer","bladder cancer"],"dc:title":["Comparison of DNA adducts in mouse bladder and lung tissue from smoke-exposed and control mice"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Medicine: Industrial Hygiene (Environmental Health)"],"thesis:degree_level":["masters"],"thesis:degree_name":["MS"],"thesis:institution_name":["University of Cincinnati"]},"updated_at":"2026-07-24T03:36:23Z"}