Development of High Strength Dicalcium Phosphate Anhydrous Cement with Nanosilica Sol

Dicalcium Phosphate Anhydrous (DCPA, Monetite) based materials have large potential as bone repair substitutes and drug delivery systems due to high bioactivity and known solubility in body fluid, and they could provide useful scaffolds in tissue engineering and orthopedic applications. Clinicians increasingly need bone scaffolds to replace autogenous tissue in endontic and orthopedic applications as an aging world population is affected by injury and disease. Dicalcium Phosphate Anhydrous is a biologically active material that can act as filler in the absence of bone. However, being a ceramic material, poor mechanical properties and fracture toughness in comparison to bone make DCPA inappropriate for complete load bearing applications. Additionally, the production of DCPA generally utilizes a high temperature exothermic reaction which is difficult to repeat and control as well as having to set before implantation in the human body. A diverse range of materials and fibers have been added to Dicalcium Phosphate Anhydrous Cements to act as reinforcements to increase their mechanical properties. The aim of this study is to produce an improved composite of augmented Dicalcium Phosphate Anhydrous Cement, through a novel microwave assisted production process, and the addition of nanosilica sol as reinforcement to increase mechanical properties. This is of interest because Silicon is a biocompatible element, which can be formed into biodegradable compounds, shown to enhance the mechanical properties of calcium phosphate cements. This study also investigates the bioactivity of this DCPA based cement infused with silica. The reported properties are designed for use in a clinical setting where a clinician needs 6-12 minutes during a surgical procedure to work with cement after mixing.

Name thesis:degree_name

Master of Science in Engineering

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Mechanical Engineering

Grantor dc:publisher

University of Toledo

Year dc:date

2012

Author dc:creator

• Luchini, Timothy John Franklin

Contributors dc:contributor

• Bhaduri, Sarit

• Biomedical Engineering
• Engineering
• Materials Science
• Mechanical Engineering
• Dicalcium Phosphate Anahydrous
• DCPA
• Monetite
• Cement
• Silica
• Increase Strength

Statement dc:rights

• unrestricted
• This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

Language dc:language

English

Repository record dc:identifier

http://rave.ohiolink.edu/etdc/view?acc_num=toledo1353010180

OAI identifier oai:identifier

oai:etd.ohiolink.edu:toledo1353010180