{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:osu1366312981"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:osu1366312981","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"A Two-Component Model For Bacterial Chemotaxis","abstract":"Chemotaxis is the directed cell movement in response to chemical signals. It iscrucial in many multicellular processes, such as wound healing, cancer metastasis,embryonic development and bioremediation. Quantitative descriptions of chemotaxiswill lead to a better understanding of the mechanisms of chemotaxis and is essentialin understanding the aforementioned processes.In this thesis, we study chemotaxis of the run-and-tumble bacteria <i>E. coli</i>. Wedevelop a mathematical model of <i>E. coli</i> chemotaxis at the single cell level. The modelconsists of two modules: The first describes how the cell transduces the external signalinto an internal signal (i.e. the change of the concentration of the intracellular proteinCheY<sub>P</sub> ). Our description is based on an existing \"trimers of dimers\" model and weimprove the parameter estimation in this work. The second module is the change ofcell movement in response to the internal CheY<sub>P</sub> change. We propose a new methodto interpret existing data on flagellar rotation. Finally we couple these two modulesand use the full model to simulate a population of cells.","abstract_html":"Chemotaxis is the directed cell movement in response to chemical signals. It iscrucial in many multicellular processes, such as wound healing, cancer metastasis,embryonic development and bioremediation. Quantitative descriptions of chemotaxiswill lead to a better understanding of the mechanisms of chemotaxis and is essentialin understanding the aforementioned processes.In this thesis, we study chemotaxis of the run-and-tumble bacteria &lt;i&gt;E. coli&lt;/i&gt;. Wedevelop a mathematical model of &lt;i&gt;E. coli&lt;/i&gt; chemotaxis at the single cell level. The modelconsists of two modules: The first describes how the cell transduces the external signalinto an internal signal (i.e. the change of the concentration of the intracellular proteinCheY&lt;sub&gt;P&lt;/sub&gt; ). Our description is based on an existing &quot;trimers of dimers&quot; model and weimprove the parameter estimation in this work. The second module is the change ofcell movement in response to the internal CheY&lt;sub&gt;P&lt;/sub&gt; change. We propose a new methodto interpret existing data on flagellar rotation. Finally we couple these two modulesand use the full model to simulate a population of cells.","abstract_has_math":false,"creators":["Durney, Clinton H."],"institution":"The Ohio State University","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Mathematics","degree_department":null,"school":null,"contributors":["Xue, Chuan"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-07-26","date_published":"2013-07-26","updated_at":"2026-07-24T03:37:16Z","subjects":["Applied Mathematics","Biology","Mathematical Biology","Chemotaxis","Mathematical Modelling"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. 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The modelconsists of two modules: The first describes how the cell transduces the external signalinto an internal signal (i.e. the change of the concentration of the intracellular proteinCheY<sub>P</sub> ). Our description is based on an existing \"trimers of dimers\" model and weimprove the parameter estimation in this work. The second module is the change ofcell movement in response to the internal CheY<sub>P</sub> change. We propose a new methodto interpret existing data on flagellar rotation. Finally we couple these two modulesand use the full model to simulate a population of cells."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","p.51","1.2 MB"]},{"key":"dc:title","label":"Title","values":["A Two-Component Model For Bacterial Chemotaxis"]}]}],"canonical_facts":{"dc:contributor":["Xue, Chuan"],"dc:creator":["Durney, Clinton H."],"dc:date":["2013-07-26"],"dc:description":["Chemotaxis is the directed cell movement in response to chemical signals. It iscrucial in many multicellular processes, such as wound healing, cancer metastasis,embryonic development and bioremediation. Quantitative descriptions of chemotaxiswill lead to a better understanding of the mechanisms of chemotaxis and is essentialin understanding the aforementioned processes.In this thesis, we study chemotaxis of the run-and-tumble bacteria <i>E. coli</i>. Wedevelop a mathematical model of <i>E. coli</i> chemotaxis at the single cell level. The modelconsists of two modules: The first describes how the cell transduces the external signalinto an internal signal (i.e. the change of the concentration of the intracellular proteinCheY<sub>P</sub> ). Our description is based on an existing \"trimers of dimers\" model and weimprove the parameter estimation in this work. The second module is the change ofcell movement in response to the internal CheY<sub>P</sub> change. We propose a new methodto interpret existing data on flagellar rotation. 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