{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:osu1365688391"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:osu1365688391","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"Biophysical Considerations in the Precision of Quantitative <sup>18</sup>F-FDG PET/CT","abstract":"As Positron Emission Tomography is increasingly being used as a functional marker of disease states, both adequate image quality and robust quantification are critical components of such imaging studies. A variety of both biological and physical factors affect these qualities in significant ways. As PET technology continues to evolve, an understanding of these effects becomes essential to the continued usefulness of PET in clinical oncology.A detailed investigation of physical elements impacting PET quantification was completed. By directly comparing the results of data sets reconstructed in various ways the true impact of reconstruction settings on quantification was revealed. It was found that changes made to factors such as the number of iterations and subsets per reconstruction or time-of-flight kernel width had a limited impact on PET quantification. However, the addition of a system point spread function correction in the reconstruction algorithm results in significant changes in quantitative measurements. When comparing this state of the art correction method to data including cutting edge time-of-flight data acquisition, further differences in quantitative measurements were found, with time-of-flight data further improving the accuracy with which activity concentrations are recovered. These results show that although there remains a need for improvement in the acquisition and reconstruction of PET data, with each system upgrade the results of PET studies are indeed coming closer to reaching a true estimation of physiological activity distributions. With this in mind, re-evaluation of the PET radiopharmaceutical dose required for adequate and robust imaging was conducted. Simulations of low-count density images showed that reducing the average image count levels by as much as 66% did not significantly impact the clinical usefulness of PET data. Therefore, maintaining current emission scan durations, a significant decrease in the standard amount of administered radioactivity could be implemented.By thoroughly detailing the quantitative impact of improving PET/CT image acquisition and reconstruction methods, it was found that there is potential for decreasing required radioactivity doses in PET/CT imaging. With the current focus on reducing patient radiation exposure in medical imaging procedures, these findings are both timely and critical in terms of the continued utilization of PET/CT imaging in oncology.","abstract_html":"As Positron Emission Tomography is increasingly being used as a functional marker of disease states, both adequate image quality and robust quantification are critical components of such imaging studies. A variety of both biological and physical factors affect these qualities in significant ways. As PET technology continues to evolve, an understanding of these effects becomes essential to the continued usefulness of PET in clinical oncology.A detailed investigation of physical elements impacting PET quantification was completed. By directly comparing the results of data sets reconstructed in various ways the true impact of reconstruction settings on quantification was revealed. It was found that changes made to factors such as the number of iterations and subsets per reconstruction or time-of-flight kernel width had a limited impact on PET quantification. However, the addition of a system point spread function correction in the reconstruction algorithm results in significant changes in quantitative measurements. When comparing this state of the art correction method to data including cutting edge time-of-flight data acquisition, further differences in quantitative measurements were found, with time-of-flight data further improving the accuracy with which activity concentrations are recovered. These results show that although there remains a need for improvement in the acquisition and reconstruction of PET data, with each system upgrade the results of PET studies are indeed coming closer to reaching a true estimation of physiological activity distributions. With this in mind, re-evaluation of the PET radiopharmaceutical dose required for adequate and robust imaging was conducted. Simulations of low-count density images showed that reducing the average image count levels by as much as 66% did not significantly impact the clinical usefulness of PET data. Therefore, maintaining current emission scan durations, a significant decrease in the standard amount of administered radioactivity could be implemented.By thoroughly detailing the quantitative impact of improving PET/CT image acquisition and reconstruction methods, it was found that there is potential for decreasing required radioactivity doses in PET/CT imaging. With the current focus on reducing patient radiation exposure in medical imaging procedures, these findings are both timely and critical in terms of the continued utilization of PET/CT imaging in oncology.","abstract_has_math":false,"creators":["Binzel, Katherine M."],"institution":"The Ohio State University","degree_name":"Doctor of Philosophy","degree_level":"doctoral","degree_discipline":"Biophysics","degree_department":null,"school":null,"contributors":["Knopp, Michael"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-08-09","date_published":"2013-08-09","updated_at":"2026-07-24T03:37:31Z","subjects":["Biophysics","Radiology","positron emission tomography"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1365688391","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Knopp, Michael"]},{"key":"dc:creator","label":"Author","values":["Binzel, Katherine M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-08-09"]},{"key":"dc:publisher","label":"Institution","values":["The Ohio State University / OhioLINK"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biophysics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["The Ohio State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biophysics","Radiology","positron emission tomography"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://rave.ohiolink.edu/etdc/view?acc_num=osu1365688391"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["As Positron Emission Tomography is increasingly being used as a functional marker of disease states, both adequate image quality and robust quantification are critical components of such imaging studies. A variety of both biological and physical factors affect these qualities in significant ways. As PET technology continues to evolve, an understanding of these effects becomes essential to the continued usefulness of PET in clinical oncology.A detailed investigation of physical elements impacting PET quantification was completed. By directly comparing the results of data sets reconstructed in various ways the true impact of reconstruction settings on quantification was revealed. It was found that changes made to factors such as the number of iterations and subsets per reconstruction or time-of-flight kernel width had a limited impact on PET quantification. However, the addition of a system point spread function correction in the reconstruction algorithm results in significant changes in quantitative measurements. When comparing this state of the art correction method to data including cutting edge time-of-flight data acquisition, further differences in quantitative measurements were found, with time-of-flight data further improving the accuracy with which activity concentrations are recovered. These results show that although there remains a need for improvement in the acquisition and reconstruction of PET data, with each system upgrade the results of PET studies are indeed coming closer to reaching a true estimation of physiological activity distributions. With this in mind, re-evaluation of the PET radiopharmaceutical dose required for adequate and robust imaging was conducted. Simulations of low-count density images showed that reducing the average image count levels by as much as 66% did not significantly impact the clinical usefulness of PET data. Therefore, maintaining current emission scan durations, a significant decrease in the standard amount of administered radioactivity could be implemented.By thoroughly detailing the quantitative impact of improving PET/CT image acquisition and reconstruction methods, it was found that there is potential for decreasing required radioactivity doses in PET/CT imaging. With the current focus on reducing patient radiation exposure in medical imaging procedures, these findings are both timely and critical in terms of the continued utilization of PET/CT imaging in oncology."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","p.135","4.5 MB"]},{"key":"dc:title","label":"Title","values":["Biophysical Considerations in the Precision of Quantitative <sup>18</sup>F-FDG PET/CT"]}]}],"canonical_facts":{"dc:contributor":["Knopp, Michael"],"dc:creator":["Binzel, Katherine M."],"dc:date":["2013-08-09"],"dc:description":["As Positron Emission Tomography is increasingly being used as a functional marker of disease states, both adequate image quality and robust quantification are critical components of such imaging studies. A variety of both biological and physical factors affect these qualities in significant ways. As PET technology continues to evolve, an understanding of these effects becomes essential to the continued usefulness of PET in clinical oncology.A detailed investigation of physical elements impacting PET quantification was completed. By directly comparing the results of data sets reconstructed in various ways the true impact of reconstruction settings on quantification was revealed. It was found that changes made to factors such as the number of iterations and subsets per reconstruction or time-of-flight kernel width had a limited impact on PET quantification. However, the addition of a system point spread function correction in the reconstruction algorithm results in significant changes in quantitative measurements. When comparing this state of the art correction method to data including cutting edge time-of-flight data acquisition, further differences in quantitative measurements were found, with time-of-flight data further improving the accuracy with which activity concentrations are recovered. These results show that although there remains a need for improvement in the acquisition and reconstruction of PET data, with each system upgrade the results of PET studies are indeed coming closer to reaching a true estimation of physiological activity distributions. With this in mind, re-evaluation of the PET radiopharmaceutical dose required for adequate and robust imaging was conducted. Simulations of low-count density images showed that reducing the average image count levels by as much as 66% did not significantly impact the clinical usefulness of PET data. Therefore, maintaining current emission scan durations, a significant decrease in the standard amount of administered radioactivity could be implemented.By thoroughly detailing the quantitative impact of improving PET/CT image acquisition and reconstruction methods, it was found that there is potential for decreasing required radioactivity doses in PET/CT imaging. With the current focus on reducing patient radiation exposure in medical imaging procedures, these findings are both timely and critical in terms of the continued utilization of PET/CT imaging in oncology."],"dc:format":["application/pdf","p.135","4.5 MB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=osu1365688391"],"dc:language":["English"],"dc:publisher":["The Ohio State University / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"dc:subject":["Biophysics","Radiology","positron emission tomography"],"dc:title":["Biophysical Considerations in the Precision of Quantitative <sup>18</sup>F-FDG PET/CT"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Biophysics"],"thesis:degree_level":["doctoral"],"thesis:degree_name":["Doctor of Philosophy"],"thesis:institution_name":["The Ohio State University"]},"updated_at":"2026-07-24T03:37:31Z"}