Gender differences in mandibular bone mineral distribution with aging

ABSTRACTObjectives: The purposes of this study were to determine 1) if cone beam computed tomography (CBCT) can determine relative differences in bone mineral density distribution using clinical images of patients’ mandibular bone and 2) if the relative differences can be used to detect the effects of gender and age on bone mineral density distribution. Methods: Sixty six clinical CBCT images from patients (36 females and 30 males) were identified. Three age groups (40, 50, and 60 years) were identified for male and female patients. Alveolar bone (AB) and basal cortical bone regions were digitally isolated. A histogram of gray levels, which are equivalent to degrees of bone mineralization, was obtained from each region of the CBCT images. Mean, standard deviation (SD), coefficient of variation (COV), fifth percentile low (Low5) and high (High5) of gray levels were obtained. Percentage differences of gray level parameters between alveolar and basal cortical bones were computed.Results: The alveolar bone region had significantly higher SD and COV, but significantly lower Mean, Low5 and High5 than the basal cortical bone region for all CBCT images (p<0.001). Significantly higher percentage differences of SD, COV, and Low5 were observed when the over 50 years old female group was compared to the male group of the same age (p<0.042).Conclusions: Significant gender differences in gray level variability observed within the postmenopausal age group suggested that the current approach to oral bone mineral density assessment using 3D clinical CBCT images can provide additional information for early diagnosis of postmenopausal osteoporosis.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Dentistry

Grantor dc:publisher

The Ohio State University

Year dc:date

2013

Author dc:creator

• Liu, Jie

Contributors dc:contributor

• Kim, Do-Gyoon

• Dentistry
• Cone Beam Computed Tomography
• Bone Mineralization
• Percentage Difference
• Menopause

Statement dc:rights

• unrestricted
• This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

Language dc:language

English

Repository record dc:identifier

http://rave.ohiolink.edu/etdc/view?acc_num=osu1365458821

OAI identifier oai:identifier

oai:etd.ohiolink.edu:osu1365458821