Ceftiofur use in animal agriculture has been disputed due to the concern over the impact it may be having on the spread of resistance genes among foodborne pathogens. Several attempts to restrict the extra label use of ceftiofur have resulted in failure until the recent FDA ban. No study has been performed to see what impact ceftiofur removal would have on the reduction of third generation cephalosporin resistance mediated by the ¿¿-lactamase gene, blaCMY-2, among Salmonella enterica and Escherichia coli organisms.
The purpose of our study was to establish a baseline prevalence of third generation cephalosporin resistance among commensal E. coli organisms as well as the prevalence of Salmonella enterica among livestock populations and their represented meat products. Following the baseline establishment, ceftiofur use was discontinued to simulate a ban on the drug use, and the organisms of interest were monitored to determine the impact on the resistance genes among the enteric microflora. Monthly fecal samples were taking from select groups of livestock, and weekly ground beef and pork samples were collected.
At the conclusion of the study, the removal of ceftiofur did not impede our ability to culture third generation cephalosporin resistant E. coli organisms from the studied livestock populations. With regards to the fresh ground meat products, organisms phenotypically resistant to third generation cephalosporins infrequently contaminate these products.¿¿¿
","abstract_html":"<p>Ceftiofur use in animal agriculture has been disputed due to the concern over the impact it may be having on the spread of resistance genes among foodborne pathogens. Several attempts to restrict the extra label use of ceftiofur have resulted in failure until the recent FDA ban. No study has been performed to see what impact ceftiofur removal would have on the reduction of third generation cephalosporin resistance mediated by the ¿¿-lactamase gene, blaCMY-2, among Salmonella enterica and Escherichia coli organisms.</p><p>The purpose of our study was to establish a baseline prevalence of third generation cephalosporin resistance among commensal E. coli organisms as well as the prevalence of Salmonella enterica among livestock populations and their represented meat products. Following the baseline establishment, ceftiofur use was discontinued to simulate a ban on the drug use, and the organisms of interest were monitored to determine the impact on the resistance genes among the enteric microflora. Monthly fecal samples were taking from select groups of livestock, and weekly ground beef and pork samples were collected.</p><p>At the conclusion of the study, the removal of ceftiofur did not impede our ability to culture third generation cephalosporin resistant E. coli organisms from the studied livestock populations. With regards to the fresh ground meat products, organisms phenotypically resistant to third generation cephalosporins infrequently contaminate these products.¿¿¿</p>","abstract_has_math":false,"creators":["Kleinhenz, Katie Elizabeth"],"institution":"The Ohio State University","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Veterinary Preventive Medicine","degree_department":null,"school":null,"contributors":["Wittum, Thomas"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-05-21","date_published":"2013-05-21","updated_at":"2026-07-24T03:36:08Z","subjects":["Epidemiology","Livestock","Antimicrobial resistance"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1357225078","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Wittum, Thomas"]},{"key":"dc:creator","label":"Author","values":["Kleinhenz, Katie Elizabeth"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-05-21"]},{"key":"dc:publisher","label":"Institution","values":["The Ohio State University / OhioLINK"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Veterinary Preventive Medicine"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["The Ohio State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Epidemiology","Livestock","Antimicrobial resistance"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://rave.ohiolink.edu/etdc/view?acc_num=osu1357225078"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Ceftiofur use in animal agriculture has been disputed due to the concern over the impact it may be having on the spread of resistance genes among foodborne pathogens. Several attempts to restrict the extra label use of ceftiofur have resulted in failure until the recent FDA ban. No study has been performed to see what impact ceftiofur removal would have on the reduction of third generation cephalosporin resistance mediated by the ¿¿-lactamase gene, blaCMY-2, among Salmonella enterica and Escherichia coli organisms.
The purpose of our study was to establish a baseline prevalence of third generation cephalosporin resistance among commensal E. coli organisms as well as the prevalence of Salmonella enterica among livestock populations and their represented meat products. Following the baseline establishment, ceftiofur use was discontinued to simulate a ban on the drug use, and the organisms of interest were monitored to determine the impact on the resistance genes among the enteric microflora. Monthly fecal samples were taking from select groups of livestock, and weekly ground beef and pork samples were collected.
At the conclusion of the study, the removal of ceftiofur did not impede our ability to culture third generation cephalosporin resistant E. coli organisms from the studied livestock populations. With regards to the fresh ground meat products, organisms phenotypically resistant to third generation cephalosporins infrequently contaminate these products.¿¿¿
"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","304.7 KB"]},{"key":"dc:title","label":"Title","values":["The Impact of Ceftiofur Removal on Recovery of Salmonella enterica and Escherichia coli Resistant to Third Generation Cephalosporins"]}]}],"canonical_facts":{"dc:contributor":["Wittum, Thomas"],"dc:creator":["Kleinhenz, Katie Elizabeth"],"dc:date":["2013-05-21"],"dc:description":["Ceftiofur use in animal agriculture has been disputed due to the concern over the impact it may be having on the spread of resistance genes among foodborne pathogens. Several attempts to restrict the extra label use of ceftiofur have resulted in failure until the recent FDA ban. No study has been performed to see what impact ceftiofur removal would have on the reduction of third generation cephalosporin resistance mediated by the ¿¿-lactamase gene, blaCMY-2, among Salmonella enterica and Escherichia coli organisms.
The purpose of our study was to establish a baseline prevalence of third generation cephalosporin resistance among commensal E. coli organisms as well as the prevalence of Salmonella enterica among livestock populations and their represented meat products. Following the baseline establishment, ceftiofur use was discontinued to simulate a ban on the drug use, and the organisms of interest were monitored to determine the impact on the resistance genes among the enteric microflora. Monthly fecal samples were taking from select groups of livestock, and weekly ground beef and pork samples were collected.
At the conclusion of the study, the removal of ceftiofur did not impede our ability to culture third generation cephalosporin resistant E. coli organisms from the studied livestock populations. With regards to the fresh ground meat products, organisms phenotypically resistant to third generation cephalosporins infrequently contaminate these products.¿¿¿
"],"dc:format":["application/pdf","304.7 KB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=osu1357225078"],"dc:language":["English"],"dc:publisher":["The Ohio State University / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"dc:subject":["Epidemiology","Livestock","Antimicrobial resistance"],"dc:title":["The Impact of Ceftiofur Removal on Recovery of Salmonella enterica and Escherichia coli Resistant to Third Generation Cephalosporins"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Veterinary Preventive Medicine"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["The Ohio State University"]},"updated_at":"2026-07-24T03:36:08Z"}