{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:osu1356624916"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:osu1356624916","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer","abstract":"Cancer diagnosis and treatment can provoke anxiety. Anxiety is accompanied by worry, which is the continual rehearsal of potential future negative consequences. Anxiety and worry in cancer patients are related to worse outcomes. However, the link between anxiety, worry and inflammation is understudied and inflammation may be one way through which anxiety and worry affect cancer outcome. The current study examined the relationship of anxiety, worry and health anxiety to inflammation in cancer patients. Women with recurrent or metastatic cancer of the breast or ovary (N=56) completed questionnaires measuring anxiety, health anxiety and worry and blood was drawn to measure inflammation, interleukins (IL), interferons (IFN) and tumor necrosis factors (TNF; IL-2, IL-4, IL-6, IL-10, IL-12, IFN-¿¿, TNF-¿¿, Granulocyte Macrophage Colony Stimulating Factor, Vascular Endothelial Growth Factor). Results indicated anxiety was positively related to humoral inflammatory markers, IL-4, while worry was positively related to IL-4 and showed a quadratic relationship to TNF-¿¿. Health anxiety was unrelated to inflammation. High levels of anxiety and worry may be related to a shift away from anti-tumor immunity and towards humoral immunity. Worry was associated with overall exhaustion of the inflammatory response as indicated by TNF-¿¿. This study suggests worry as a future intervention target in cancer patients as well as an important factor in models of adaptation to the stress of cancer.","abstract_html":"Cancer diagnosis and treatment can provoke anxiety. Anxiety is accompanied by worry, which is the continual rehearsal of potential future negative consequences. Anxiety and worry in cancer patients are related to worse outcomes. However, the link between anxiety, worry and inflammation is understudied and inflammation may be one way through which anxiety and worry affect cancer outcome. The current study examined the relationship of anxiety, worry and health anxiety to inflammation in cancer patients. Women with recurrent or metastatic cancer of the breast or ovary (N=56) completed questionnaires measuring anxiety, health anxiety and worry and blood was drawn to measure inflammation, interleukins (IL), interferons (IFN) and tumor necrosis factors (TNF; IL-2, IL-4, IL-6, IL-10, IL-12, IFN-¿¿, TNF-¿¿, Granulocyte Macrophage Colony Stimulating Factor, Vascular Endothelial Growth Factor). Results indicated anxiety was positively related to humoral inflammatory markers, IL-4, while worry was positively related to IL-4 and showed a quadratic relationship to TNF-¿¿. Health anxiety was unrelated to inflammation. High levels of anxiety and worry may be related to a shift away from anti-tumor immunity and towards humoral immunity. Worry was associated with overall exhaustion of the inflammatory response as indicated by TNF-¿¿. This study suggests worry as a future intervention target in cancer patients as well as an important factor in models of adaptation to the stress of cancer.","abstract_has_math":false,"creators":["Wu, Salene M."],"institution":"The Ohio State University","degree_name":"Doctor of Philosophy","degree_level":"doctoral","degree_discipline":"Psychology","degree_department":null,"school":null,"contributors":["Andersen, Barbara"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-05-22","date_published":"2013-05-22","updated_at":"2026-07-24T03:36:08Z","subjects":["Psychology","cancer","oncology","anxiety","worry","inflammation","immunity"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://rave.ohiolink.edu/etdc/view?acc_num=osu1356624916","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Andersen, Barbara"]},{"key":"dc:creator","label":"Author","values":["Wu, Salene M."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-05-22"]},{"key":"dc:publisher","label":"Institution","values":["The Ohio State University / OhioLINK"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["The Ohio State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Psychology","cancer","oncology","anxiety","worry","inflammation","immunity"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. 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Women with recurrent or metastatic cancer of the breast or ovary (N=56) completed questionnaires measuring anxiety, health anxiety and worry and blood was drawn to measure inflammation, interleukins (IL), interferons (IFN) and tumor necrosis factors (TNF; IL-2, IL-4, IL-6, IL-10, IL-12, IFN-¿¿, TNF-¿¿, Granulocyte Macrophage Colony Stimulating Factor, Vascular Endothelial Growth Factor). Results indicated anxiety was positively related to humoral inflammatory markers, IL-4, while worry was positively related to IL-4 and showed a quadratic relationship to TNF-¿¿. Health anxiety was unrelated to inflammation. High levels of anxiety and worry may be related to a shift away from anti-tumor immunity and towards humoral immunity. Worry was associated with overall exhaustion of the inflammatory response as indicated by TNF-¿¿. This study suggests worry as a future intervention target in cancer patients as well as an important factor in models of adaptation to the stress of cancer."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","p.137","992.6 KB"]},{"key":"dc:title","label":"Title","values":["Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer"]}]}],"canonical_facts":{"dc:contributor":["Andersen, Barbara"],"dc:creator":["Wu, Salene M."],"dc:date":["2013-05-22"],"dc:description":["Cancer diagnosis and treatment can provoke anxiety. Anxiety is accompanied by worry, which is the continual rehearsal of potential future negative consequences. Anxiety and worry in cancer patients are related to worse outcomes. However, the link between anxiety, worry and inflammation is understudied and inflammation may be one way through which anxiety and worry affect cancer outcome. The current study examined the relationship of anxiety, worry and health anxiety to inflammation in cancer patients. Women with recurrent or metastatic cancer of the breast or ovary (N=56) completed questionnaires measuring anxiety, health anxiety and worry and blood was drawn to measure inflammation, interleukins (IL), interferons (IFN) and tumor necrosis factors (TNF; IL-2, IL-4, IL-6, IL-10, IL-12, IFN-¿¿, TNF-¿¿, Granulocyte Macrophage Colony Stimulating Factor, Vascular Endothelial Growth Factor). Results indicated anxiety was positively related to humoral inflammatory markers, IL-4, while worry was positively related to IL-4 and showed a quadratic relationship to TNF-¿¿. Health anxiety was unrelated to inflammation. High levels of anxiety and worry may be related to a shift away from anti-tumor immunity and towards humoral immunity. Worry was associated with overall exhaustion of the inflammatory response as indicated by TNF-¿¿. This study suggests worry as a future intervention target in cancer patients as well as an important factor in models of adaptation to the stress of cancer."],"dc:format":["application/pdf","p.137","992.6 KB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=osu1356624916"],"dc:language":["English"],"dc:publisher":["The Ohio State University / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws."],"dc:subject":["Psychology","cancer","oncology","anxiety","worry","inflammation","immunity"],"dc:title":["Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Psychology"],"thesis:degree_level":["doctoral"],"thesis:degree_name":["Doctor of Philosophy"],"thesis:institution_name":["The Ohio State University"]},"updated_at":"2026-07-24T03:36:08Z"}