The Photophysics and Transport Properties of Non-Covalent Silicon Phthalocyanine Gold Nanoparticle Conjugates

Nanomedicine has shown great promise for the treatment of a variety of complex diseases including cancer. The use of nanomaterials for non-covalent drug delivery has shown great success in the delivery of photodynamic therapy drugs in animal models, and has great potential as a general delivery vector for hydrophobic drugs. A detailed understanding of what physical forces dictate efficacy in the loading, transport, and delivery of non-covalent drugs is required for optimization and clinical translation. This thesis examines the non-covalent interactions between silicon phthalocyanine 4 (Pc 4) and polyethylene glycol coated gold nanoparticles (PEGylated Au NPs) through photophysics and transport studies. A detailed investigation of Pc 4’s photophysical behavior in water both with and without Au NPs is presented, elucidating the role of intramolecular photoinduced electron transfer and aggregation behavior. Gel electrophoresis studies of PEGylated Au NPs described in this work provide insights on fundamental physical properties of NPs as well as the local environment through which they translate. This thesis provides a “bottom-up” approach to non-covalent drug delivery which will be helpful in translating non-covalent drug delivery to more complex systems.

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

doctoral

Discipline thesis:degree_discipline

Chemistry

Grantor dc:publisher

Case Western Reserve University School of Graduate Studies

Year dc:date

2013

Author dc:creator

• Doane, Tennyson L., III

Contributors dc:contributor

• Burda, Clemens
• Gray, Thomas

• Chemistry
• Physical Chemistry
• Phthalocyanines
• Femtosecond Spectroscopy
• Nanoparticles
• Transport Properties
• Drug Delivery

Statement dc:rights

• unrestricted
• This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.

Language dc:language

English

Repository record dc:identifier

http://rave.ohiolink.edu/etdc/view?acc_num=case1365175186

OAI identifier oai:identifier

oai:etd.ohiolink.edu:case1365175186