{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:case1365110648"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:case1365110648","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"Acf7 is a Hair-Bundle Antecedent, Positioned to Integrate Cuticular Plate Actin and Somatic Tubulin","abstract":"The hair cell of the inner ear converts mechanical stimuli, such as sound waves, into electrical impulses which are then sent to and interpreted by the brain. Proper organization of the actin and microtubule cytoskeletons is important for establishing the distinct morphology of the hair cell, which is crucial for its function. Here we identify the genes ACF7, MYO9A, and MYO9B are expressed in hair cells, and may be important for hair cell development and function. Through zebrafish transgenesis and indirect labeling of mouse hair cells we show that ACF7 is positioned to integrate the actin and microtubule networks in hair cells. In addition, electron micrographs demonstrate microtubules inserting into the cuticular plate, the ends of which are decorated with proteins that directly link to the F-actin of the cuticular plate. ACF7, which possesses both actin and microtubule binding domains, is a prime candidate to be this linker.","abstract_html":"The hair cell of the inner ear converts mechanical stimuli, such as sound waves, into electrical impulses which are then sent to and interpreted by the brain. Proper organization of the actin and microtubule cytoskeletons is important for establishing the distinct morphology of the hair cell, which is crucial for its function. Here we identify the genes ACF7, MYO9A, and MYO9B are expressed in hair cells, and may be important for hair cell development and function. Through zebrafish transgenesis and indirect labeling of mouse hair cells we show that ACF7 is positioned to integrate the actin and microtubule networks in hair cells. In addition, electron micrographs demonstrate microtubules inserting into the cuticular plate, the ends of which are decorated with proteins that directly link to the F-actin of the cuticular plate. ACF7, which possesses both actin and microtubule binding domains, is a prime candidate to be this linker.","abstract_has_math":false,"creators":["Antonellis, Patrick Joseph"],"institution":"Case Western Reserve University School of Graduate Studies","degree_name":"Master of Sciences","degree_level":"masters","degree_discipline":"Biology","degree_department":null,"school":null,"contributors":["McDermott, Brian"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-08-16","date_published":"2013-08-16","updated_at":"2026-07-24T03:37:16Z","subjects":["Biology","Molecular Biology","Cellular Biology"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. 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Through zebrafish transgenesis and indirect labeling of mouse hair cells we show that ACF7 is positioned to integrate the actin and microtubule networks in hair cells. In addition, electron micrographs demonstrate microtubules inserting into the cuticular plate, the ends of which are decorated with proteins that directly link to the F-actin of the cuticular plate. 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Through zebrafish transgenesis and indirect labeling of mouse hair cells we show that ACF7 is positioned to integrate the actin and microtubule networks in hair cells. In addition, electron micrographs demonstrate microtubules inserting into the cuticular plate, the ends of which are decorated with proteins that directly link to the F-actin of the cuticular plate. ACF7, which possesses both actin and microtubule binding domains, is a prime candidate to be this linker."],"dc:format":["application/pdf","p.57","2.61 MB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=case1365110648"],"dc:language":["English"],"dc:publisher":["Case Western Reserve University School of Graduate Studies / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: all rights reserved. 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