{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:case1364982246"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:case1364982246","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers","abstract":"The in vivo foreign body reaction on biomaterials regarding development of foreign body giant cells and formation of fibrous capsules was studied. The first study (chapter II) discusses the development of foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 (interleukin-4) cytokine. The experiment consisted of in vivo subcutaneous implants of polyether urethane (PEU) and polyethylene terephthalate (PET) in immunodeficient mice strains. Analysis on polymer surfaces using quantitative calculations such as percent fusion, cell density, and nuclei density described the development of foreign body reaction on biomaterial surface. In addition qualitative assessment was implemented to also describe the development of foreign body reaction that provided similar characterization to the quantitative calculations. The second study (chapter III) focuses on the fibrous capsule formation around biomaterials. Electrospun nanofibers poly(e-caprolactone-co-ethylethylene phosphate) coupled with collagen type I siRNA were subcutaneously implanted. A significant decrease in fibrous capsule thickness at weeks 2 and 4 were shown compared to the control nanofibers.","abstract_html":"The in vivo foreign body reaction on biomaterials regarding development of foreign body giant cells and formation of fibrous capsules was studied. The first study (chapter II) discusses the development of foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 (interleukin-4) cytokine. The experiment consisted of in vivo subcutaneous implants of polyether urethane (PEU) and polyethylene terephthalate (PET) in immunodeficient mice strains. Analysis on polymer surfaces using quantitative calculations such as percent fusion, cell density, and nuclei density described the development of foreign body reaction on biomaterial surface. In addition qualitative assessment was implemented to also describe the development of foreign body reaction that provided similar characterization to the quantitative calculations. The second study (chapter III) focuses on the fibrous capsule formation around biomaterials. Electrospun nanofibers poly(e-caprolactone-co-ethylethylene phosphate) coupled with collagen type I siRNA were subcutaneously implanted. A significant decrease in fibrous capsule thickness at weeks 2 and 4 were shown compared to the control nanofibers.","abstract_has_math":false,"creators":["Yang, Jung Hoon"],"institution":"Case Western Reserve University School of Graduate Studies","degree_name":"Master of Sciences","degree_level":"masters","degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Anderson , James"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-08-19","date_published":"2013-08-19","updated_at":"2026-07-24T03:37:16Z","subjects":["Biomedical Engineering","Foreign Body Reaction","Foreign Body Giant Cell Formation","Immunodeficient Mice","siRNA","Fibrous Capsule down regulation"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1364982246","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Anderson , James"]},{"key":"dc:creator","label":"Author","values":["Yang, Jung Hoon"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-08-19"]},{"key":"dc:publisher","label":"Institution","values":["Case Western Reserve University School of Graduate Studies / OhioLINK"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Sciences"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Case Western Reserve University School of Graduate Studies"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biomedical Engineering","Foreign Body Reaction","Foreign Body Giant Cell Formation","Immunodeficient Mice","siRNA","Fibrous Capsule down regulation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["unrestricted","This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://rave.ohiolink.edu/etdc/view?acc_num=case1364982246"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The in vivo foreign body reaction on biomaterials regarding development of foreign body giant cells and formation of fibrous capsules was studied. The first study (chapter II) discusses the development of foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 (interleukin-4) cytokine. The experiment consisted of in vivo subcutaneous implants of polyether urethane (PEU) and polyethylene terephthalate (PET) in immunodeficient mice strains. Analysis on polymer surfaces using quantitative calculations such as percent fusion, cell density, and nuclei density described the development of foreign body reaction on biomaterial surface. In addition qualitative assessment was implemented to also describe the development of foreign body reaction that provided similar characterization to the quantitative calculations. The second study (chapter III) focuses on the fibrous capsule formation around biomaterials. Electrospun nanofibers poly(e-caprolactone-co-ethylethylene phosphate) coupled with collagen type I siRNA were subcutaneously implanted. A significant decrease in fibrous capsule thickness at weeks 2 and 4 were shown compared to the control nanofibers."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","p.106","5.97 MB"]},{"key":"dc:title","label":"Title","values":["In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers"]}]}],"canonical_facts":{"dc:contributor":["Anderson , James"],"dc:creator":["Yang, Jung Hoon"],"dc:date":["2013-08-19"],"dc:description":["The in vivo foreign body reaction on biomaterials regarding development of foreign body giant cells and formation of fibrous capsules was studied. The first study (chapter II) discusses the development of foreign body reaction with specific lymphocytic immunodeficient mice mainly targeting IL-4 (interleukin-4) cytokine. The experiment consisted of in vivo subcutaneous implants of polyether urethane (PEU) and polyethylene terephthalate (PET) in immunodeficient mice strains. Analysis on polymer surfaces using quantitative calculations such as percent fusion, cell density, and nuclei density described the development of foreign body reaction on biomaterial surface. In addition qualitative assessment was implemented to also describe the development of foreign body reaction that provided similar characterization to the quantitative calculations. The second study (chapter III) focuses on the fibrous capsule formation around biomaterials. Electrospun nanofibers poly(e-caprolactone-co-ethylethylene phosphate) coupled with collagen type I siRNA were subcutaneously implanted. A significant decrease in fibrous capsule thickness at weeks 2 and 4 were shown compared to the control nanofibers."],"dc:format":["application/pdf","p.106","5.97 MB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=case1364982246"],"dc:language":["English"],"dc:publisher":["Case Western Reserve University School of Graduate Studies / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center."],"dc:subject":["Biomedical Engineering","Foreign Body Reaction","Foreign Body Giant Cell Formation","Immunodeficient Mice","siRNA","Fibrous Capsule down regulation"],"dc:title":["In Vivo Studies of the Foreign Body Reaction to Biomedical Polymers"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Sciences"],"thesis:institution_name":["Case Western Reserve University School of Graduate Studies"]},"updated_at":"2026-07-24T03:37:16Z"}