{"id":{"repo_id":"ohiolink","oai_identifier":"oai:etd.ohiolink.edu:case1364514398"},"canonical_url":"https://search.dev.ndltd.org/etd/ohiolink/oai:etd.ohiolink.edu:case1364514398","repository":{"repo_id":"ohiolink","name":"OhioLINK","base_url":"https://etd.ohiolink.edu/acprod/odb_etd/ws/oai/oai"},"display":{"title":"Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease","abstract":"Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's Disease (PD). The efficacy is believed to be dependent on high rates of exercise. In this study, we use functional connectivity (FC) MRI to further elucidate the mechanism underlying this rate-dependent effect. PD subjects were randomized to complete 8 weeks of forced, voluntary, or no exercise. Changes in brain connectivity were then analyzed as a function of pedaling rate. Changes in task-related FC (trFC) from the most affected motor cortex (*M1) to the ipsilateral thalamus were significantly positively correlated to pedaling rate. Changes in trFC between *M1 and the supplementary motor area were significantly negatively correlated to pedaling rate. This relationship persisted after 4 weeks of follow up. This indicates that patients who pedal faster tend to show stronger increases in cortico-subcortical trFC, and stronger decreases in cortico-cortical trFC.","abstract_html":"Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's Disease (PD). The efficacy is believed to be dependent on high rates of exercise. In this study, we use functional connectivity (FC) MRI to further elucidate the mechanism underlying this rate-dependent effect. PD subjects were randomized to complete 8 weeks of forced, voluntary, or no exercise. Changes in brain connectivity were then analyzed as a function of pedaling rate. Changes in task-related FC (trFC) from the most affected motor cortex (*M1) to the ipsilateral thalamus were significantly positively correlated to pedaling rate. Changes in trFC between *M1 and the supplementary motor area were significantly negatively correlated to pedaling rate. This relationship persisted after 4 weeks of follow up. This indicates that patients who pedal faster tend to show stronger increases in cortico-subcortical trFC, and stronger decreases in cortico-cortical trFC.","abstract_has_math":false,"creators":["Shah, Chintan"],"institution":"Case Western Reserve University School of Graduate Studies","degree_name":"Master of Sciences (Engineering)","degree_level":"masters","degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Gustafson, Kenneth","Alberts, Jay"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-08-19","date_published":"2013-08-19","updated_at":"2026-07-24T03:37:01Z","subjects":["Biomedical Engineering","Medical Imaging","Neurosciences","Parkinson's Disease","exercise","Functional Connectivity","fMRI","fcMRI"],"languages":["English"],"rights":["unrestricted","This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://rave.ohiolink.edu/etdc/view?acc_num=case1364514398","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Gustafson, Kenneth","Alberts, Jay"]},{"key":"dc:creator","label":"Author","values":["Shah, Chintan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-08-19"]},{"key":"dc:publisher","label":"Institution","values":["Case Western Reserve University School of Graduate Studies / OhioLINK"]},{"key":"dc:type","label":"Dc Type","values":["Electronic Thesis or Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Sciences (Engineering)"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Case Western Reserve University School of Graduate Studies"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biomedical Engineering","Medical Imaging","Neurosciences","Parkinson's Disease","exercise","Functional Connectivity","fMRI","fcMRI"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]},{"key":"dc:rights","label":"Dc Rights","values":["unrestricted","This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://rave.ohiolink.edu/etdc/view?acc_num=case1364514398"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's Disease (PD). The efficacy is believed to be dependent on high rates of exercise. In this study, we use functional connectivity (FC) MRI to further elucidate the mechanism underlying this rate-dependent effect. PD subjects were randomized to complete 8 weeks of forced, voluntary, or no exercise. Changes in brain connectivity were then analyzed as a function of pedaling rate. Changes in task-related FC (trFC) from the most affected motor cortex (*M1) to the ipsilateral thalamus were significantly positively correlated to pedaling rate. Changes in trFC between *M1 and the supplementary motor area were significantly negatively correlated to pedaling rate. This relationship persisted after 4 weeks of follow up. This indicates that patients who pedal faster tend to show stronger increases in cortico-subcortical trFC, and stronger decreases in cortico-cortical trFC."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf","p.51","1.07 MB"]},{"key":"dc:title","label":"Title","values":["Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease"]}]}],"canonical_facts":{"dc:contributor":["Gustafson, Kenneth","Alberts, Jay"],"dc:creator":["Shah, Chintan"],"dc:date":["2013-08-19"],"dc:description":["Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's Disease (PD). The efficacy is believed to be dependent on high rates of exercise. In this study, we use functional connectivity (FC) MRI to further elucidate the mechanism underlying this rate-dependent effect. PD subjects were randomized to complete 8 weeks of forced, voluntary, or no exercise. Changes in brain connectivity were then analyzed as a function of pedaling rate. Changes in task-related FC (trFC) from the most affected motor cortex (*M1) to the ipsilateral thalamus were significantly positively correlated to pedaling rate. Changes in trFC between *M1 and the supplementary motor area were significantly negatively correlated to pedaling rate. This relationship persisted after 4 weeks of follow up. This indicates that patients who pedal faster tend to show stronger increases in cortico-subcortical trFC, and stronger decreases in cortico-cortical trFC."],"dc:format":["application/pdf","p.51","1.07 MB"],"dc:identifier":["http://rave.ohiolink.edu/etdc/view?acc_num=case1364514398"],"dc:language":["English"],"dc:publisher":["Case Western Reserve University School of Graduate Studies / OhioLINK"],"dc:rights":["unrestricted","This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center."],"dc:subject":["Biomedical Engineering","Medical Imaging","Neurosciences","Parkinson's Disease","exercise","Functional Connectivity","fMRI","fcMRI"],"dc:title":["Effects of Exercise Therapy on Functional Connectivity in Parkinson's Disease"],"dc:type":["Electronic Thesis or Dissertation"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Sciences (Engineering)"],"thesis:institution_name":["Case Western Reserve University School of Graduate Studies"]},"updated_at":"2026-07-24T03:37:01Z"}