Donepezil’s Effect on Cardiac Function in Patients with Alzheimer’s Disease through an In Vivo, Non Invasive Measure of Cardiac Autonomic Function

<p>The aim of the current study was to explore the effects of the medication Donepezil (Aricept®) on cardiac autonomic function for individuals diagnosed with mild to moderate (probable) Alzheimer’s disease (AD). Using age (± 3 years) and gender matched controls, differences in heart rate variability (HRV) among individuals with Alzheimer’s disease were compared to healthy controls over a period of six months (session 1 [baseline], session 2 [3 months], and session 3 [6 months]) in both supine and standing positions. HRV was obtained through frequency-domain (Low Frequency Power, High Frequency Power, RMSSD, LF/HF Ratio) and time-domain (six minutes) measures using ECG technology. Data were analyzed using 2x2x2 (AD group n= 12; HC group n= 12) and 2x2x3 (AD group n= 8; HC group n= 8) repeated measures ANCOVA’s while controlling for age, gender, body mass index (BMI), blood pressure, medications, dose of Donepezil (Aricept®), alcohol use, caffeine use, and physical activity. Results from the ANCOVA did not reveal statistically significant between group differences for the HRV frequency-domain measures. However, data indicated a trend towards greater reductions in normalized high frequency power (parasympathetic depression) and greater increases in normalized low frequency power (sympathetic exacerbation) among the AD group versus healthy controls at all three time points despite the use of Donepezil (Aricept®).</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Psychology

Year dc:date.available

2015

Author dc:creator

• Hackett, Lewis P.

Contributors dc:contributor

• Serina A. Neumann
• Desideria S. Hacker
• Michael L. Stutts
• Richard W. Handel
• Hamid Okhravi

• Alzheimer's disease
• Cholinesterase inhibitor
• Heart rate variability
• Clinical Psychology

Statement dc:rights

• <p>In Copyright. URI: <a href="http://rightsstatements.org/vocab/InC/1.0/">http://rightsstatements.org/vocab/InC/1.0/</a> This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).</p>

Identifier

9781339109190

OAI identifier oai:identifier

oai:digitalcommons.odu.edu:psychology_etds-1009