Role of Estrogenic Biomarkers in the Prediction of Disease Risk/Survival in Postmenopausal Women

The role of estrogens extends far beyond that of sexual development in females. Results from population-based studies indicate that estrogenic factors have a role to play in diseases affecting postmenopausal women. However studies investigating the role of estrogenic biomarkers in association to these diseases is lacking, especially in Asians. Using the Singapore Chinese Health Study Cohort in Singapore, we investigated the role of estrogenic biomarkers by the measurement of estrogen levels and Estrogen Receptor (ER) cell based bioassays in association with risk of hip fracture and breast cancer. In addition, we use these estrogenic biomarkers to predict survival in a hospital based case control study of postmenopausal lung cancer. These studies show that the measurement of estrogen levels and/or ER mediated bioactivity in the serum of postmenopausal women have the potential to increase accuracy of risk prediction of these diseases and provide insights on the mechanisms of cancer initiation and progression.

Author dc:creator

• LIM WEI XUN VANESSA

• Estrogen Receptor Bioactivity, Estrogens, Postmenopausal women, Breast Cancer, Hip Fracture, Lung Cancer