{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/49361"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/49361","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"SPATIOTEMPORAL CONTROL OF THE SALT STRESS INDUCED TRANSCRIPTIONAL RESPONSE IN ARABIDOPSIS","abstract":"My study is focused on how different signaling pathways are integrated spatiotemporally under salt stress and how transcriptional regulation occurs. Firstly, I did an analysis on a previously generated spatiotemporal transcriptional map of salt stress in Arabidopsis roots, covering 4 core cell types and 6 time points for salt treatment. Based on this spatiotemporal map, the transcriptional changes of key components in hormone biosynthesis and signaling were identified, and a bioinformatics method was also developed to systematically de-convolve the hormone crosstalk network with salt stress, identifying some salt stress response sub-modules controlled by hormone signaling. Second, I developed an efficient pipeline to study the biological functions of cis-regulatory elements which are good starting points for the generation of a CRE centered transcriptional network involved in the salt stress response in the Arabidopsis roots. Using this pipeline, I validated the regulatory functions of seven CREs and two other previously unknown elements.","abstract_html":"My study is focused on how different signaling pathways are integrated spatiotemporally under salt stress and how transcriptional regulation occurs. Firstly, I did an analysis on a previously generated spatiotemporal transcriptional map of salt stress in Arabidopsis roots, covering 4 core cell types and 6 time points for salt treatment. Based on this spatiotemporal map, the transcriptional changes of key components in hormone biosynthesis and signaling were identified, and a bioinformatics method was also developed to systematically de-convolve the hormone crosstalk network with salt stress, identifying some salt stress response sub-modules controlled by hormone signaling. Second, I developed an efficient pipeline to study the biological functions of cis-regulatory elements which are good starting points for the generation of a CRE centered transcriptional network involved in the salt stress response in the Arabidopsis roots. Using this pipeline, I validated the regulatory functions of seven CREs and two other previously unknown elements.","abstract_has_math":false,"creators":["WU RUI"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-08-22","date_published":"2013-08-22","updated_at":"2026-07-24T03:31:38Z","subjects":["Arabidopsis root, salt stress, transcriptional regulation, spatiotemporal, CRE, synthetic promoter,"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["WU RUI"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2013-08-22"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/49361"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Arabidopsis root, salt stress, transcriptional regulation, spatiotemporal, CRE, synthetic promoter,"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/70483bc1-445a-4d37-a65d-9f353be507ab/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["My study is focused on how different signaling pathways are integrated spatiotemporally under salt stress and how transcriptional regulation occurs. Firstly, I did an analysis on a previously generated spatiotemporal transcriptional map of salt stress in Arabidopsis roots, covering 4 core cell types and 6 time points for salt treatment. Based on this spatiotemporal map, the transcriptional changes of key components in hormone biosynthesis and signaling were identified, and a bioinformatics method was also developed to systematically de-convolve the hormone crosstalk network with salt stress, identifying some salt stress response sub-modules controlled by hormone signaling. Second, I developed an efficient pipeline to study the biological functions of cis-regulatory elements which are good starting points for the generation of a CRE centered transcriptional network involved in the salt stress response in the Arabidopsis roots. 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Based on this spatiotemporal map, the transcriptional changes of key components in hormone biosynthesis and signaling were identified, and a bioinformatics method was also developed to systematically de-convolve the hormone crosstalk network with salt stress, identifying some salt stress response sub-modules controlled by hormone signaling. Second, I developed an efficient pipeline to study the biological functions of cis-regulatory elements which are good starting points for the generation of a CRE centered transcriptional network involved in the salt stress response in the Arabidopsis roots. 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