{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/35576"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/35576","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"ASYMMETRIC ORGANOCATALYTIC HENRY REACTION OF β–SUBSTITUTED α-KETO ESTERS VIA DYNAMIC KINETIC RESOLUTION","abstract":"This thesis describes the development of diastereo- and enantioselective Henry reaction of ß-substituted a-keto esters using cinchona alkaloid derived bifunctional catalyst via dynamic kinetic resolution. Chapter 1 presents a brief historical background and development of asymmetric catalysis. Particularly, the asymmetric organocatalysis is introduced in detail. Then the historical background and development of dynamic kinetic resolution are summarized, especially, those organocatalytic methods are introduced in detail. In Chapter 2, the diastereo- and enantioselective Henry reactions of ß-substituted a-keto esters via dynamic kinetic resolution are investigated by using cinchona alkaloid derived bifunctional catalysts. Our approach combines organocatalytic Henry reaction and concept of dynamic kinetic resolution, and it also provides an access to biologically important and medicinal useful pyrrolidine derivatives.","abstract_html":"This thesis describes the development of diastereo- and enantioselective Henry reaction of ß-substituted a-keto esters using cinchona alkaloid derived bifunctional catalyst via dynamic kinetic resolution. Chapter 1 presents a brief historical background and development of asymmetric catalysis. Particularly, the asymmetric organocatalysis is introduced in detail. Then the historical background and development of dynamic kinetic resolution are summarized, especially, those organocatalytic methods are introduced in detail. In Chapter 2, the diastereo- and enantioselective Henry reactions of ß-substituted a-keto esters via dynamic kinetic resolution are investigated by using cinchona alkaloid derived bifunctional catalysts. Our approach combines organocatalytic Henry reaction and concept of dynamic kinetic resolution, and it also provides an access to biologically important and medicinal useful pyrrolidine derivatives.","abstract_has_math":false,"creators":["LIU GUANNAN"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-08-03","date_published":"2012-08-03","updated_at":"2026-07-24T03:33:22Z","subjects":["asymmetric,organocatalytic,henry reaction,nitroaldol reaction,DKR,α-ketoester"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["LIU GUANNAN"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2012-08-03"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/35576"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["asymmetric,organocatalytic,henry reaction,nitroaldol reaction,DKR,α-ketoester"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/e869d2d1-f5de-465f-986e-aaf0763f4954/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This thesis describes the development of diastereo- and enantioselective Henry reaction of ß-substituted a-keto esters using cinchona alkaloid derived bifunctional catalyst via dynamic kinetic resolution. 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Then the historical background and development of dynamic kinetic resolution are summarized, especially, those organocatalytic methods are introduced in detail. In Chapter 2, the diastereo- and enantioselective Henry reactions of ß-substituted a-keto esters via dynamic kinetic resolution are investigated by using cinchona alkaloid derived bifunctional catalysts. 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