IMPLANT MATERIAL FUNCTIONALIZATION TO ENHANCE BIOACTIVITY IN ORTHOPAEDICS

Musculoskeletal disease is one of the leading causes of long term physical disability. One of the key challenges in bone healing and regeneration is the engineering of an implant that incorporates osseointegration to meet the metabolic demands of recovery. Although implants are typically expected to last ten years or more, longevity is still not assured and the lack of integration into the bone for long-term survival often occurs and leads to implant failure.Revision surgery to address such failure involves increased risks, complications and costs. The main reason for the failure of these implants is due to aseptic loosening. The success of implants is highly dependent on firm bonding or fixation of implant biomaterial to bone, for optimal function and lastingness. Thus the aim of this thesis is to develop orthopaedic implant materials with enhanced bioactivity and improved implant-host interactions so as to reduce biological related implant failure.

Author dc:creator

• POH CHYE KHOON

• Orthopaedics, Implants, Bioactivity, Surface functionalization, Growth Factors, Metallic Alloys