FOLATE RECEPTOR TARGETED LIPOSOMES AS THE ENABLING TECHNOLOGY FOR THE DELIVERY OF CHEMOTHERAPEUTICS IN THE TREATMENT OF OVARIAN CANCER
type: CreativeWork
description: Chemotherapeutic agents encapsulated in FR-targeted liposomes have shown potential for increased therapeutic efficacy and decreased toxicity. Folate receptors are over-expressed in almost 90% of the ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could present a viable treatment option for the FR over-expressing ovarian cancers. The aim of this thesis was to develop a folate receptor targeted liposomal formulation of carboplatin and to evaluate its in vitro and in vivo efficacy in FR over-expressing tumors. The optimised FR-targeted (FRT) carboplatin formulation showed significantly higher drug loading, stability, controlled release and superior cytotoxicity in FR-positive cell lines. Superior survival rates (>83%) were achieved in IGROV1 tumor bearing mice when treated intra-peritoneally with FRT liposomes. In summary, this thesis was successful in developing a folate receptor targeted carboplatin liposomal formulation which showed tremendous therapeutic potential for the localised therapy of FR-positive ovarian cancer with significantly improved survival benefits.
abstract: Chemotherapeutic agents encapsulated in FR-targeted liposomes have shown potential for increased therapeutic efficacy and decreased toxicity. Folate receptors are over-expressed in almost 90% of the ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could present a viable treatment option for the FR over-expressing ovarian cancers. The aim of this thesis was to develop a folate receptor targeted liposomal formulation of carboplatin and to evaluate its in vitro and in vivo efficacy in FR over-expressing tumors. The optimised FR-targeted (FRT) carboplatin formulation showed significantly higher drug loading, stability, controlled release and superior cytotoxicity in FR-positive cell lines. Superior survival rates (>83%) were achieved in IGROV1 tumor bearing mice when treated intra-peritoneally with FRT liposomes. In summary, this thesis was successful in developing a folate receptor targeted carboplatin liposomal formulation which showed tremendous therapeutic potential for the localised therapy of FR-positive ovarian cancer with significantly improved survival benefits.
author: ANUMITA CHAUDHURY
keywords: folate-receptor, targeted, liposomes, ovarian cancer, carboplatin, lyophilisation
date published: 2011-08-03
date modified: 2026-07-24T03:30:47Z
provider: National University of Singapore
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: National University of Singapore