{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/30025"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/30025","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"FOLATE RECEPTOR TARGETED LIPOSOMES AS THE ENABLING TECHNOLOGY FOR THE DELIVERY OF CHEMOTHERAPEUTICS IN THE TREATMENT OF OVARIAN CANCER","abstract":"Chemotherapeutic agents encapsulated in FR-targeted liposomes have shown potential for increased therapeutic efficacy and decreased toxicity. Folate receptors are over-expressed in almost 90% of the ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could present a viable treatment option for the FR over-expressing ovarian cancers. The aim of this thesis was to develop a folate receptor targeted liposomal formulation of carboplatin and to evaluate its in vitro and in vivo efficacy in FR over-expressing tumors. The optimised FR-targeted (FRT) carboplatin formulation showed significantly higher drug loading, stability, controlled release and superior cytotoxicity in FR-positive cell lines. Superior survival rates (>83%) were achieved in IGROV1 tumor bearing mice when treated intra-peritoneally with FRT liposomes. In summary, this thesis was successful in developing a folate receptor targeted carboplatin liposomal formulation which showed tremendous therapeutic potential for the localised therapy of FR-positive ovarian cancer with significantly improved survival benefits.","abstract_html":"Chemotherapeutic agents encapsulated in FR-targeted liposomes have shown potential for increased therapeutic efficacy and decreased toxicity. Folate receptors are over-expressed in almost 90% of the ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could present a viable treatment option for the FR over-expressing ovarian cancers. The aim of this thesis was to develop a folate receptor targeted liposomal formulation of carboplatin and to evaluate its in vitro and in vivo efficacy in FR over-expressing tumors. The optimised FR-targeted (FRT) carboplatin formulation showed significantly higher drug loading, stability, controlled release and superior cytotoxicity in FR-positive cell lines. Superior survival rates (>83%) were achieved in IGROV1 tumor bearing mice when treated intra-peritoneally with FRT liposomes. In summary, this thesis was successful in developing a folate receptor targeted carboplatin liposomal formulation which showed tremendous therapeutic potential for the localised therapy of FR-positive ovarian cancer with significantly improved survival benefits.","abstract_has_math":false,"creators":["ANUMITA CHAUDHURY"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["CHIU NGAR CHEE, GIGI"],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-08-03","date_published":"2011-08-03","updated_at":"2026-08-21T16:47:23Z","subjects":["folate-receptor, targeted, liposomes, ovarian cancer, carboplatin, lyophilisation"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarbank.nus.edu.sg/handle/10635/30025","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://scholarbank.nus.edu.sg/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Ascholarbank.nus.edu.sg%3A10635%2F30025","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["PHARMACY"]},{"key":"dc:contributor.supervisor","label":"Supervisor","values":["CHIU NGAR CHEE, GIGI"]},{"key":"dc:creator","label":"Author","values":["ANUMITA CHAUDHURY"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2012-01-09T18:00:20Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2012-01-09T18:00:20Z"]},{"key":"dc:date.issued","label":"Date","values":["2011-08-03"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/30025"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["folate-receptor, targeted, liposomes, ovarian cancer, carboplatin, lyophilisation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/0062e5f4-ad5c-4493-af21-eb656fda1063/download","https://scholarbank.nus.edu.sg/handle/10635/30025"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Chemotherapeutic agents encapsulated in FR-targeted liposomes have shown potential for increased therapeutic efficacy and decreased toxicity. Folate receptors are over-expressed in almost 90% of the ovarian cancers. Thus intracellular delivery of carboplatin through FR targeted liposomes could present a viable treatment option for the FR over-expressing ovarian cancers. The aim of this thesis was to develop a folate receptor targeted liposomal formulation of carboplatin and to evaluate its in vitro and in vivo efficacy in FR over-expressing tumors. The optimised FR-targeted (FRT) carboplatin formulation showed significantly higher drug loading, stability, controlled release and superior cytotoxicity in FR-positive cell lines. Superior survival rates (>83%) were achieved in IGROV1 tumor bearing mice when treated intra-peritoneally with FRT liposomes. In summary, this thesis was successful in developing a folate receptor targeted carboplatin liposomal formulation which showed tremendous therapeutic potential for the localised therapy of FR-positive ovarian cancer with significantly improved survival benefits."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Ph.D"]},{"key":"dc:format.checksum.md5","label":"Dc Format Checksum Md5","values":["719da5bc364686acbd1aedb6f76124cd","72c9eff650850650efdb2f46c372e33a"]},{"key":"dc:title","label":"Title","values":["FOLATE RECEPTOR TARGETED LIPOSOMES AS THE ENABLING TECHNOLOGY FOR THE DELIVERY OF CHEMOTHERAPEUTICS IN THE TREATMENT OF OVARIAN CANCER"]}]}],"canonical_facts":{"dc:contributor.other":["PHARMACY"],"dc:contributor.supervisor":["CHIU NGAR CHEE, GIGI"],"dc:creator":["ANUMITA CHAUDHURY"],"dc:date.accessioned":["2012-01-09T18:00:20Z"],"dc:date.available":["2012-01-09T18:00:20Z"],"dc:date.issued":["2011-08-03"],"dc:description.abstract":["Chemotherapeutic agents encapsulated in FR-targeted liposomes have shown potential for increased therapeutic efficacy and decreased toxicity. 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