{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/244778"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/244778","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"FLEXIBLE GEL IMPLANT LOADED WITH PERSISTENT LUMINESCE NANOPARTICLES FOR PHOTOTHERAPY IN DEEP TISSUES","abstract":"Phototherapy, an effective medical treatment using light with minimal side effects, is limited for deep-seated diseases due to low UV and visible light penetration (1-3 mm). While X-rays penetrate deeper, their direct use in phototherapy is challenging for optogenetic and photodynamic therapies, as they cannot activate opsins and photosensitizers. To overcome this, nanotransducers converting X-rays to UV/visible light are used. Among them, X-ray activated persistence luminescence nanoparticles (PLNPs) gained interest. PLNPs emit light continuously for several minutes to hours, reducing X-ray-induced damage. This thesis proposes using X-ray-activated NaLuF4 PLNPs co-doped withTb and Gd for deep tissue phototherapy. The study explores enhancing luminescence by coating PLNPs with an inert NaYF4 shell and pre-investigates their biocompatibility and loading into epoxy resin or PDMS for clinical applications. Insights from this study enable effective deep-seated phototherapy for diseases in deep tissues.","abstract_html":"Phototherapy, an effective medical treatment using light with minimal side effects, is limited for deep-seated diseases due to low UV and visible light penetration (1-3 mm). While X-rays penetrate deeper, their direct use in phototherapy is challenging for optogenetic and photodynamic therapies, as they cannot activate opsins and photosensitizers. To overcome this, nanotransducers converting X-rays to UV/visible light are used. Among them, X-ray activated persistence luminescence nanoparticles (PLNPs) gained interest. PLNPs emit light continuously for several minutes to hours, reducing X-ray-induced damage. This thesis proposes using X-ray-activated NaLuF4 PLNPs co-doped withTb and Gd for deep tissue phototherapy. The study explores enhancing luminescence by coating PLNPs with an inert NaYF4 shell and pre-investigates their biocompatibility and loading into epoxy resin or PDMS for clinical applications. 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Among them, X-ray activated persistence luminescence nanoparticles (PLNPs) gained interest. PLNPs emit light continuously for several minutes to hours, reducing X-ray-induced damage. This thesis proposes using X-ray-activated NaLuF4 PLNPs co-doped withTb and Gd for deep tissue phototherapy. The study explores enhancing luminescence by coating PLNPs with an inert NaYF4 shell and pre-investigates their biocompatibility and loading into epoxy resin or PDMS for clinical applications. 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