{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/185041"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/185041","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"THE RNA-BINDING PROTEIN LRP1 MEDIATES FLOWERING TIME IN ARABIDOPSIS","abstract":"In flowering plants such as <i>Arabidopsis thaliana</i>, floral transition is tightly regulated by a complex network of genetic pathways. FLOWERING LOCUS C (FLC), a MADS-box transcription factor, is a strong repressor of this flowering process, intricately controlled by several genetic pathways, including the autonomous pathway. We show that LATE FLOWERING RNA-BINDING PROTEIN 1 (LRP1), an RNA-binding protein, promotes flowering through modulating <i>FLC</i> mRNA levels. <i>LRP1</i> mRNA is highly expressed in shoot apices and young leaves, while its protein is localized in the cytoplasm and nucleus. <i>lrp1</i> mutants show a late-flowering phenotype in both long-day and short-day conditions with greatly upregulated <i>FLC</i> mRNA levels. Mutations in <i>FLC</i> completely suppress the late-flowering phenotype of <i>lrp1</i>, suggesting that <i>FLC</i> is a major target of <i>LRP1</i>. LRP1 also forms a protein complex with a splicing factor, SR45, indicating that LRP1 may function together with SR45 to modulate <i>FLC</i> mRNA levels.","abstract_html":"In flowering plants such as &lt;i&gt;Arabidopsis thaliana&lt;/i&gt;, floral transition is tightly regulated by a complex network of genetic pathways. FLOWERING LOCUS C (FLC), a MADS-box transcription factor, is a strong repressor of this flowering process, intricately controlled by several genetic pathways, including the autonomous pathway. We show that LATE FLOWERING RNA-BINDING PROTEIN 1 (LRP1), an RNA-binding protein, promotes flowering through modulating &lt;i&gt;FLC&lt;/i&gt; mRNA levels. &lt;i&gt;LRP1&lt;/i&gt; mRNA is highly expressed in shoot apices and young leaves, while its protein is localized in the cytoplasm and nucleus. &lt;i&gt;lrp1&lt;/i&gt; mutants show a late-flowering phenotype in both long-day and short-day conditions with greatly upregulated &lt;i&gt;FLC&lt;/i&gt; mRNA levels. Mutations in &lt;i&gt;FLC&lt;/i&gt; completely suppress the late-flowering phenotype of &lt;i&gt;lrp1&lt;/i&gt;, suggesting that &lt;i&gt;FLC&lt;/i&gt; is a major target of &lt;i&gt;LRP1&lt;/i&gt;. LRP1 also forms a protein complex with a splicing factor, SR45, indicating that LRP1 may function together with SR45 to modulate &lt;i&gt;FLC&lt;/i&gt; mRNA levels.","abstract_has_math":false,"creators":["HUANG QING"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020-08-17","date_published":"2020-08-17","updated_at":"2026-07-24T03:32:43Z","subjects":["LLPS","protein interaction","flowering promoter","M6A","SR45","FLC"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["HUANG QING"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2020-08-17"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/185041"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["LLPS","protein interaction","flowering promoter","M6A","SR45","FLC"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/afbdc40c-c5b5-4042-9e1a-4392b489b90d/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In flowering plants such as <i>Arabidopsis thaliana</i>, floral transition is tightly regulated by a complex network of genetic pathways. FLOWERING LOCUS C (FLC), a MADS-box transcription factor, is a strong repressor of this flowering process, intricately controlled by several genetic pathways, including the autonomous pathway. We show that LATE FLOWERING RNA-BINDING PROTEIN 1 (LRP1), an RNA-binding protein, promotes flowering through modulating <i>FLC</i> mRNA levels. <i>LRP1</i> mRNA is highly expressed in shoot apices and young leaves, while its protein is localized in the cytoplasm and nucleus. <i>lrp1</i> mutants show a late-flowering phenotype in both long-day and short-day conditions with greatly upregulated <i>FLC</i> mRNA levels. Mutations in <i>FLC</i> completely suppress the late-flowering phenotype of <i>lrp1</i>, suggesting that <i>FLC</i> is a major target of <i>LRP1</i>. LRP1 also forms a protein complex with a splicing factor, SR45, indicating that LRP1 may function together with SR45 to modulate <i>FLC</i> mRNA levels."]},{"key":"dc:format.checksum.md5","label":"Dc Format Checksum Md5","values":["8f7bab54c3d0492303d2b65025abceef","ee986ad123b69aade2d1f8da14129d04"]},{"key":"dc:title","label":"Title","values":["THE RNA-BINDING PROTEIN LRP1 MEDIATES FLOWERING TIME IN ARABIDOPSIS"]}]}],"canonical_facts":{"dc:creator":["HUANG QING"],"dc:date.issued":["2020-08-17"],"dc:description.abstract":["In flowering plants such as <i>Arabidopsis thaliana</i>, floral transition is tightly regulated by a complex network of genetic pathways. FLOWERING LOCUS C (FLC), a MADS-box transcription factor, is a strong repressor of this flowering process, intricately controlled by several genetic pathways, including the autonomous pathway. We show that LATE FLOWERING RNA-BINDING PROTEIN 1 (LRP1), an RNA-binding protein, promotes flowering through modulating <i>FLC</i> mRNA levels. <i>LRP1</i> mRNA is highly expressed in shoot apices and young leaves, while its protein is localized in the cytoplasm and nucleus. <i>lrp1</i> mutants show a late-flowering phenotype in both long-day and short-day conditions with greatly upregulated <i>FLC</i> mRNA levels. Mutations in <i>FLC</i> completely suppress the late-flowering phenotype of <i>lrp1</i>, suggesting that <i>FLC</i> is a major target of <i>LRP1</i>. LRP1 also forms a protein complex with a splicing factor, SR45, indicating that LRP1 may function together with SR45 to modulate <i>FLC</i> mRNA levels."],"dc:format.checksum.md5":["8f7bab54c3d0492303d2b65025abceef","ee986ad123b69aade2d1f8da14129d04"],"dc:identifier.uri":["https://scholarbank.nus.edu.sg/bitstreams/afbdc40c-c5b5-4042-9e1a-4392b489b90d/download"],"dc:relation.isreferencedby":["https://scholarbank.nus.edu.sg/handle/10635/185041"],"dc:subject":["LLPS","protein interaction","flowering promoter","M6A","SR45","FLC"],"dc:title":["THE RNA-BINDING PROTEIN LRP1 MEDIATES FLOWERING TIME IN ARABIDOPSIS"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T03:32:43Z"}