{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/17979"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/17979","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"In vitro and in vivo assessments of PCL-TCP composites for bone tissue engineering","abstract":"Currently, there is an unmet need for bone grafts which is the gold standard of treating patients with trauma related injuries or bone fracture. Autologous bone graft poses no issues of rejection but will result in donor site morbidity and is limited by defect size. Allografts and xenografts are not as popular due to the increased risk of disease transmission, high cost and graft rejection. Shortcomings of current bone grafts motivate researchers to look into polymer composites for better substitutes. PCL-TCP composites have demonstrated excellent biocompatibility, degradation profile and ability to incorporate cells and growth factors in both in vitro and in vivo model. The main aim in this thesis is to further evaluate and improve on the current properties of PCL-TCP composites from various aspects namely porosity and cell modulators.","abstract_html":"Currently, there is an unmet need for bone grafts which is the gold standard of treating patients with trauma related injuries or bone fracture. Autologous bone graft poses no issues of rejection but will result in donor site morbidity and is limited by defect size. Allografts and xenografts are not as popular due to the increased risk of disease transmission, high cost and graft rejection. Shortcomings of current bone grafts motivate researchers to look into polymer composites for better substitutes. PCL-TCP composites have demonstrated excellent biocompatibility, degradation profile and ability to incorporate cells and growth factors in both in vitro and in vivo model. The main aim in this thesis is to further evaluate and improve on the current properties of PCL-TCP composites from various aspects namely porosity and cell modulators.","abstract_has_math":false,"creators":["WONG WAH JIE (WANG HEJIE)"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["TEOH SWEE HIN"],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-01-04","date_published":"2010-01-04","updated_at":"2026-08-21T16:47:23Z","subjects":["bone, PCL-TCP, porosity, heparin, dispersion, BMP-2"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarbank.nus.edu.sg/handle/10635/17979","outbound_label":"Repository record","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://scholarbank.nus.edu.sg/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Ascholarbank.nus.edu.sg%3A10635%2F17979","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["MECHANICAL ENGINEERING"]},{"key":"dc:contributor.supervisor","label":"Supervisor","values":["TEOH SWEE HIN"]},{"key":"dc:creator","label":"Author","values":["WONG WAH JIE (WANG HEJIE)"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-09-03T18:00:26Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-09-03T18:00:26Z"]},{"key":"dc:date.issued","label":"Date","values":["2010-01-04"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/17979"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["bone, PCL-TCP, porosity, heparin, dispersion, BMP-2"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/5f048cba-9fb7-466e-8fdc-2f639ac2e5a5/download","https://scholarbank.nus.edu.sg/handle/10635/17979"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Currently, there is an unmet need for bone grafts which is the gold standard of treating patients with trauma related injuries or bone fracture. 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