LIPID-RELATED CORONARY RISK PROFILE IN SINGAPORE NEWBORNS : RACIAL AND MOLECULAR GENETIC ASPECTS
type: CreativeWork
description: Coronary artery disease (CAD) is a major cause of morbidity and premature mortality worldwide and in Singapore. Among the three major ethnic groups in the Singapore population, a diversity of incidence rates of CAD has been observed with prevalence rates of CAD lowest in ethnic Chinese, intermediate in ethnic Malays and highest in ethnic Indians. Despite a common socio-economic environment for generations, the difference in CAD prevalence rates seen in these three ethnic groups was maintained and is probably inherent and related to ethnicity. Plasma lipid, lipoprotein, apolipoproteins and lipoprotein(a) [Lp(a)] levels have been established as risk factors for CAD. The adult population of Singapore has shown ethnic specific plasma lipid profiles in accordance to their relative level of coronary risk. This study was designed to look into the profile of the plasma lipid traits in the newborns of the three ethnic groups in Singapore in order to characterise according to race, their coronary risk levels at birth using cord blood specimens. DNA polymorphisms of the apolipoprotein B and E genes have been shown to be associated with variations in plasma lipid, lipoprotein and apolipoprotein levels with consequent influence on the prevalence of CAD. The insertion/deletion (I/D) polymorphism of the ACE gene was also found to be an important coronary risk factor and is of particular significance in those afflicted with myocardial infarction despite considered to be at low risk by conventional risk markers. The molecular profile of the apo B, apo E and ACE gene polymorphisms in the newborns of Indians and Chinese was studied to complement the racial aspects of the newborn lipid profile. Malays are genetically heterogeneous and are a mixture of Chinese and Indians. The effect of these DNA polymorphisms in plasma lipid traits was also analysed to find out if these genes are expressed at the time of birth. Chapters 4 to 6 of this study report the coronary risk profile as defined b…
abstract: Coronary artery disease (CAD) is a major cause of morbidity and premature mortality worldwide and in Singapore. Among the three major ethnic groups in the Singapore population, a diversity of incidence rates of CAD has been observed with prevalence rates of CAD lowest in ethnic Chinese, intermediate in ethnic Malays and highest in ethnic Indians. Despite a common socio-economic environment for generations, the difference in CAD prevalence rates seen in these three ethnic groups was maintained and is probably inherent and related to ethnicity. Plasma lipid, lipoprotein, apolipoproteins and lipoprotein(a) [Lp(a)] levels have been established as risk factors for CAD. The adult population of Singapore has shown ethnic specific plasma lipid profiles in accordance to their relative level of coronary risk. This study was designed to look into the profile of the plasma lipid traits in the newborns of the three ethnic groups in Singapore in order to characterise according to race, their coronary risk levels at birth using cord blood specimens. DNA polymorphisms of the apolipoprotein B and E genes have been shown to be associated with variations in plasma lipid, lipoprotein and apolipoprotein levels with consequent influence on the prevalence of CAD. The insertion/deletion (I/D) polymorphism of the ACE gene was also found to be an important coronary risk factor and is of particular significance in those afflicted with myocardial infarction despite considered to be at low risk by conventional risk markers. The molecular profile of the apo B, apo E and ACE gene polymorphisms in the newborns of Indians and Chinese was studied to complement the racial aspects of the newborn lipid profile. Malays are genetically heterogeneous and are a mixture of Chinese and Indians. The effect of these DNA polymorphisms in plasma lipid traits was also analysed to find out if these genes are expressed at the time of birth. Chapters 4 to 6 of this study report the coronary risk profile as defined b…
author: LOW POH SIM
date published: 1996
date modified: 2026-07-24T03:32:18Z
provider: National University of Singapore
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: National University of Singapore