{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/16626"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/16626","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"Chemokines as therapeutic targets in systematic inflammatory response syndrome","abstract":"Exaggerated systemic inflammatory response syndrome may lead to multiple organ dysfunction, organ failure and eventually death. Chemokines, a large family of small chemotactic cytokines, are critical inflammatory mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage of CCR1 by a small molecule CCR1 antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by compound 48/80 has also attenuated acute pancreatitis-associated lung injury and sepsis-associated lung injury by attenuating the levels of chemokines. Treatment with an exogenous CX3C chemokine FTK has shown pro-inflammatory effect in acute pancreatitis-associated lung injury and anti-inflammatory effect against sepsis-associated lung injury. These promising findings validate that manipulating chemokine system may have protective effect in systemic inflammatory response syndrome.","abstract_html":"Exaggerated systemic inflammatory response syndrome may lead to multiple organ dysfunction, organ failure and eventually death. Chemokines, a large family of small chemotactic cytokines, are critical inflammatory mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage of CCR1 by a small molecule CCR1 antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by compound 48/80 has also attenuated acute pancreatitis-associated lung injury and sepsis-associated lung injury by attenuating the levels of chemokines. Treatment with an exogenous CX3C chemokine FTK has shown pro-inflammatory effect in acute pancreatitis-associated lung injury and anti-inflammatory effect against sepsis-associated lung injury. These promising findings validate that manipulating chemokine system may have protective effect in systemic inflammatory response syndrome.","abstract_has_math":false,"creators":["HE MIN"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-12-16","date_published":"2008-12-16","updated_at":"2026-07-24T03:32:18Z","subjects":["chemokines, sepsis, acute pancreatitis"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["HE MIN"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2008-12-16"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/16626"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["chemokines, sepsis, acute pancreatitis"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/03176382-e9a7-4917-8eea-2ead2f05024a/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Exaggerated systemic inflammatory response syndrome may lead to multiple organ dysfunction, organ failure and eventually death. Chemokines, a large family of small chemotactic cytokines, are critical inflammatory mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage of CCR1 by a small molecule CCR1 antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by compound 48/80 has also attenuated acute pancreatitis-associated lung injury and sepsis-associated lung injury by attenuating the levels of chemokines. Treatment with an exogenous CX3C chemokine FTK has shown pro-inflammatory effect in acute pancreatitis-associated lung injury and anti-inflammatory effect against sepsis-associated lung injury. These promising findings validate that manipulating chemokine system may have protective effect in systemic inflammatory response syndrome."]},{"key":"dc:format.checksum.md5","label":"Dc Format Checksum Md5","values":["40fe2d97e29cf723a6bfbe5090bb4ca3","c3842e2e8295fb017d74110a078a8499"]},{"key":"dc:title","label":"Title","values":["Chemokines as therapeutic targets in systematic inflammatory response syndrome"]}]}],"canonical_facts":{"dc:creator":["HE MIN"],"dc:date.issued":["2008-12-16"],"dc:description.abstract":["Exaggerated systemic inflammatory response syndrome may lead to multiple organ dysfunction, organ failure and eventually death. Chemokines, a large family of small chemotactic cytokines, are critical inflammatory mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage of CCR1 by a small molecule CCR1 antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by compound 48/80 has also attenuated acute pancreatitis-associated lung injury and sepsis-associated lung injury by attenuating the levels of chemokines. Treatment with an exogenous CX3C chemokine FTK has shown pro-inflammatory effect in acute pancreatitis-associated lung injury and anti-inflammatory effect against sepsis-associated lung injury. 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