{"id":{"repo_id":"nus","oai_identifier":"oai:scholarbank.nus.edu.sg:10635/13002"},"canonical_url":"https://search.dev.ndltd.org/etd/nus/oai:scholarbank.nus.edu.sg:10635/13002","repository":{"repo_id":"nus","name":"National University of Singapore","base_url":"https://scholarbank.nus.edu.sg/oai/request"},"display":{"title":"Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury","abstract":"Tachykinins and neurokinin receptors are implicated in the neurogenic inflammation (NI) during acute pancreatitis (AP). The effects of neurokinin receptor antagonists on caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and associated lung injury. Present study demonstrated that CP96,345 treatment affected the release of substance P (SP), the expression of neurokinin receptor and tachykinin genes, and the expression of various adhesion molecules, in pancreas and lungs. A similar expression pattern was seen by immunohistochemical reactivity. Our results suggested a differential pattern of regulation of inflammatory response in pancreas and lungs. Finally, leukocyte-endothelial interaction in pancreatic microcirculation was visualized using intravital microscopy. CP96,345 significantly decreases the number of rolling and adherent leukocytes. In summary, blockade of SP-NK1R system, the major component of NI, has been proven to be effective in the treatment of AP and associated lung injury in mouse.","abstract_html":"Tachykinins and neurokinin receptors are implicated in the neurogenic inflammation (NI) during acute pancreatitis (AP). The effects of neurokinin receptor antagonists on caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and associated lung injury. Present study demonstrated that CP96,345 treatment affected the release of substance P (SP), the expression of neurokinin receptor and tachykinin genes, and the expression of various adhesion molecules, in pancreas and lungs. A similar expression pattern was seen by immunohistochemical reactivity. Our results suggested a differential pattern of regulation of inflammatory response in pancreas and lungs. Finally, leukocyte-endothelial interaction in pancreatic microcirculation was visualized using intravital microscopy. CP96,345 significantly decreases the number of rolling and adherent leukocytes. In summary, blockade of SP-NK1R system, the major component of NI, has been proven to be effective in the treatment of AP and associated lung injury in mouse.","abstract_has_math":false,"creators":["LAU HON YEN"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-01-23","date_published":"2008-01-23","updated_at":"2026-07-24T03:33:34Z","subjects":["acute pancreatitis, neurogenic inflammation, neurokinin receptor, tachykinin, pancreas, lung"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["LAU HON YEN"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2008-01-23"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://scholarbank.nus.edu.sg/handle/10635/13002"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["acute pancreatitis, neurogenic inflammation, neurokinin receptor, tachykinin, pancreas, lung"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://scholarbank.nus.edu.sg/bitstreams/fe4ac6db-8e8c-4cbe-ad29-6282bb0b5486/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Tachykinins and neurokinin receptors are implicated in the neurogenic inflammation (NI) during acute pancreatitis (AP). The effects of neurokinin receptor antagonists on caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and associated lung injury. Present study demonstrated that CP96,345 treatment affected the release of substance P (SP), the expression of neurokinin receptor and tachykinin genes, and the expression of various adhesion molecules, in pancreas and lungs. A similar expression pattern was seen by immunohistochemical reactivity. Our results suggested a differential pattern of regulation of inflammatory response in pancreas and lungs. Finally, leukocyte-endothelial interaction in pancreatic microcirculation was visualized using intravital microscopy. CP96,345 significantly decreases the number of rolling and adherent leukocytes. In summary, blockade of SP-NK1R system, the major component of NI, has been proven to be effective in the treatment of AP and associated lung injury in mouse."]},{"key":"dc:format.checksum.md5","label":"Dc Format Checksum Md5","values":["626ff53cc18fd0d17879f56423c5a3d3","1a5fff8a1f069df0ecff9ed53c07d6d1"]},{"key":"dc:title","label":"Title","values":["Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury"]}]}],"canonical_facts":{"dc:creator":["LAU HON YEN"],"dc:date.issued":["2008-01-23"],"dc:description.abstract":["Tachykinins and neurokinin receptors are implicated in the neurogenic inflammation (NI) during acute pancreatitis (AP). The effects of neurokinin receptor antagonists on caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and associated lung injury. Present study demonstrated that CP96,345 treatment affected the release of substance P (SP), the expression of neurokinin receptor and tachykinin genes, and the expression of various adhesion molecules, in pancreas and lungs. A similar expression pattern was seen by immunohistochemical reactivity. Our results suggested a differential pattern of regulation of inflammatory response in pancreas and lungs. Finally, leukocyte-endothelial interaction in pancreatic microcirculation was visualized using intravital microscopy. CP96,345 significantly decreases the number of rolling and adherent leukocytes. In summary, blockade of SP-NK1R system, the major component of NI, has been proven to be effective in the treatment of AP and associated lung injury in mouse."],"dc:format.checksum.md5":["626ff53cc18fd0d17879f56423c5a3d3","1a5fff8a1f069df0ecff9ed53c07d6d1"],"dc:identifier.uri":["https://scholarbank.nus.edu.sg/bitstreams/fe4ac6db-8e8c-4cbe-ad29-6282bb0b5486/download"],"dc:relation.isreferencedby":["https://scholarbank.nus.edu.sg/handle/10635/13002"],"dc:subject":["acute pancreatitis, neurogenic inflammation, neurokinin receptor, tachykinin, pancreas, lung"],"dc:title":["Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T03:33:34Z"}