{"id":{"repo_id":"nott-trent","oai_identifier":"oai:irep.ntu.ac.uk:53"},"canonical_url":"https://search.dev.ndltd.org/etd/nott-trent/oai:irep.ntu.ac.uk:53","repository":{"repo_id":"nott-trent","name":"Nottingham Trent University","base_url":"https://irep.ntu.ac.uk/cgi/oai2"},"display":{"title":"A study of immune responses to Leishmania mexicana antigens and immunogenicity of L. donovani Centrin-3","abstract":"Leishmaniasis is a parasitic protozoal disease affecting humans and animals with phlebotomine sand flies as intermediate vectors. The parasite infects phagocytic cells of the mammalian host where they transform from the flagellated promastigote to non-flagellated amastigote phase. There is no effective vaccine in use against this parasite and production relies on finding potent immunogenic antigens with a Th1 bias and long lasting memory response. In this study the immunogenicity of L. mexicana Soluble Leishmania Antigens (SLA) prepared by two different methods (SLA1&2) was investigated by immunisation of Balb/c mice and challenge with live L. mexicana and an in vitro immunological analysis. Immunisation of Balb/c mice with SLA mixed with IFA adjuvant significantly protected against challenge with live L. mexicana parasites.","abstract_html":"Leishmaniasis is a parasitic protozoal disease affecting humans and animals with phlebotomine sand flies as intermediate vectors. The parasite infects phagocytic cells of the mammalian host where they transform from the flagellated promastigote to non-flagellated amastigote phase. There is no effective vaccine in use against this parasite and production relies on finding potent immunogenic antigens with a Th1 bias and long lasting memory response. In this study the immunogenicity of L. mexicana Soluble Leishmania Antigens (SLA) prepared by two different methods (SLA1&2) was investigated by immunisation of Balb/c mice and challenge with live L. mexicana and an in vitro immunological analysis. Immunisation of Balb/c mice with SLA mixed with IFA adjuvant significantly protected against challenge with live L. mexicana parasites.","abstract_has_math":false,"creators":["Asteal, F"],"institution":"Nottingham Trent University","degree_name":"phd","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-24T06:30:42Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Asteal, F"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011"]},{"key":"dc:date.issued","label":"Date","values":["2011"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Nottingham Trent University"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://irep.ntu.ac.uk/id/eprint/53/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["phd"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://irep.ntu.ac.uk/id/eprint/53/1/203552_final%20thesis1Fathiya%20Asteal.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Leishmaniasis is a parasitic protozoal disease affecting humans and animals with phlebotomine sand flies as intermediate vectors. The parasite infects phagocytic cells of the mammalian host where they transform from the flagellated promastigote to non-flagellated amastigote phase. There is no effective vaccine in use against this parasite and production relies on finding potent immunogenic antigens with a Th1 bias and long lasting memory response. In this study the immunogenicity of L. mexicana Soluble Leishmania Antigens (SLA) prepared by two different methods (SLA1&2) was investigated by immunisation of Balb/c mice and challenge with live L. mexicana and an in vitro immunological analysis. Immunisation of Balb/c mice with SLA mixed with IFA adjuvant significantly protected against challenge with live L. mexicana parasites."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["A study of immune responses to Leishmania mexicana antigens and immunogenicity of L. donovani Centrin-3"]}]}],"canonical_facts":{"dc:creator":["Asteal, F"],"dc:date":["2011"],"dc:date.issued":["2011"],"dc:description.abstract":["Leishmaniasis is a parasitic protozoal disease affecting humans and animals with phlebotomine sand flies as intermediate vectors. The parasite infects phagocytic cells of the mammalian host where they transform from the flagellated promastigote to non-flagellated amastigote phase. There is no effective vaccine in use against this parasite and production relies on finding potent immunogenic antigens with a Th1 bias and long lasting memory response. In this study the immunogenicity of L. mexicana Soluble Leishmania Antigens (SLA) prepared by two different methods (SLA1&2) was investigated by immunisation of Balb/c mice and challenge with live L. mexicana and an in vitro immunological analysis. Immunisation of Balb/c mice with SLA mixed with IFA adjuvant significantly protected against challenge with live L. mexicana parasites."],"dc:format":["text"],"dc:identifier.uri":["https://irep.ntu.ac.uk/id/eprint/53/1/203552_final%20thesis1Fathiya%20Asteal.pdf"],"dc:language":["en"],"dc:publisher.institution":["Nottingham Trent University"],"dc:relation.isreferencedby":["https://irep.ntu.ac.uk/id/eprint/53/"],"dc:title":["A study of immune responses to Leishmania mexicana antigens and immunogenicity of L. donovani Centrin-3"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["phd"]},"updated_at":"2026-07-24T06:30:42Z"}