{"id":{"repo_id":"northampton","oai_identifier":"oai:pure.atira.dk:studenttheses/46ddba5f-c171-4491-8b1e-07c63468be9d"},"canonical_url":"https://search.dev.ndltd.org/etd/northampton/oai:pure.atira.dk:studenttheses/46ddba5f-c171-4491-8b1e-07c63468be9d","repository":{"repo_id":"northampton","name":"University of Northampton","base_url":"https://pure.northampton.ac.uk/ws/oai"},"display":{"title":"Inter-individual variation in saliva antioxidant status in relation to periodontal disease","abstract":"Free radicals have been implicated in the aetiology of many human disease states, including periodontal disease (PD). Saliva contains an array of antioxidants that neutralise the harmful effects of free radical formation within the oral cavity. Increased salivary antioxidant capacity may limit oxidative tissue damage and improve the health of the gingival tissues. In this thesis, the antioxidant profile of saliva was assessed in relation to PD severity. Salivary protein carbonyl concentration was assessed as a biomarker of oxidative tissue damage. Urate, ascorbate and albumin contributed 85% of the total scavenging antioxidant capacity (TAA) which followed a diurnal rhythm (peak 5.OOpm, nadir 3.OOam). Salivary antioxidant flow rate was significantly lower in individuals with severe PD (TAA 0.2 10 ± 0.02 M/ml/min) than those with healthy gingivae (TAA 0.270 ± 0.02 iiM/ml/min) (p","abstract_html":"Free radicals have been implicated in the aetiology of many human disease states, including periodontal disease (PD). Saliva contains an array of antioxidants that neutralise the harmful effects of free radical formation within the oral cavity. Increased salivary antioxidant capacity may limit oxidative tissue damage and improve the health of the gingival tissues. In this thesis, the antioxidant profile of saliva was assessed in relation to PD severity. Salivary protein carbonyl concentration was assessed as a biomarker of oxidative tissue damage. Urate, ascorbate and albumin contributed 85% of the total scavenging antioxidant capacity (TAA) which followed a diurnal rhythm (peak 5.OOpm, nadir 3.OOam). Salivary antioxidant flow rate was significantly lower in individuals with severe PD (TAA 0.2 10 ± 0.02 M/ml/min) than those with healthy gingivae (TAA 0.270 ± 0.02 iiM/ml/min) (p","abstract_has_math":false,"creators":["Sculley, Dean Vincent"],"institution":"University of Northampton","degree_name":"Doctoral Thesis","degree_level":"Student thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Campbell, Jacqueline Ann"],"committee_chairs":[],"committee_members":[],"year":2004,"date_issued":"2004","date_published":"2004","updated_at":"2026-07-24T03:26:33Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.atira.dk:studenttheses/46ddba5f-c171-4491-8b1e-07c63468be9d"],"render_values":[{"text":"oai:pure.atira.dk:studenttheses/46ddba5f-c171-4491-8b1e-07c63468be9d","href":null,"code":true}]}]},"links":{"outbound_url":"https://pure.northampton.ac.uk/en/studentTheses/46ddba5f-c171-4491-8b1e-07c63468be9d","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Campbell, Jacqueline Ann"]},{"key":"dc:creator","label":"Author","values":["Sculley, Dean Vincent"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2004"]},{"key":"dc:date.issued","label":"Date","values":["2004"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Northampton"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://pure.northampton.ac.uk/en/studentTheses/46ddba5f-c171-4491-8b1e-07c63468be9d"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Student thesis"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["Doctoral Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:pure.atira.dk:studenttheses/46ddba5f-c171-4491-8b1e-07c63468be9d","https://pure.northampton.ac.uk/en/studentTheses/46ddba5f-c171-4491-8b1e-07c63468be9d"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Free radicals have been implicated in the aetiology of many human disease states, including periodontal disease (PD). Saliva contains an array of antioxidants that neutralise the harmful effects of free radical formation within the oral cavity. Increased salivary antioxidant capacity may limit oxidative tissue damage and improve the health of the gingival tissues. In this thesis, the antioxidant profile of saliva was assessed in relation to PD severity. Salivary protein carbonyl concentration was assessed as a biomarker of oxidative tissue damage. Urate, ascorbate and albumin contributed 85% of the total scavenging antioxidant capacity (TAA) which followed a diurnal rhythm (peak 5.OOpm, nadir 3.OOam). Salivary antioxidant flow rate was significantly lower in individuals with severe PD (TAA 0.2 10 ± 0.02 M/ml/min) than those with healthy gingivae (TAA 0.270 ± 0.02 iiM/ml/min) (p"]},{"key":"dc:title","label":"Title","values":["Inter-individual variation in saliva antioxidant status in relation to periodontal disease"]}]}],"canonical_facts":{"dc:contributor.advisor":["Campbell, Jacqueline Ann"],"dc:creator":["Sculley, Dean Vincent"],"dc:date":["2004"],"dc:date.issued":["2004"],"dc:description.abstract":["Free radicals have been implicated in the aetiology of many human disease states, including periodontal disease (PD). Saliva contains an array of antioxidants that neutralise the harmful effects of free radical formation within the oral cavity. Increased salivary antioxidant capacity may limit oxidative tissue damage and improve the health of the gingival tissues. In this thesis, the antioxidant profile of saliva was assessed in relation to PD severity. Salivary protein carbonyl concentration was assessed as a biomarker of oxidative tissue damage. Urate, ascorbate and albumin contributed 85% of the total scavenging antioxidant capacity (TAA) which followed a diurnal rhythm (peak 5.OOpm, nadir 3.OOam). Salivary antioxidant flow rate was significantly lower in individuals with severe PD (TAA 0.2 10 ± 0.02 M/ml/min) than those with healthy gingivae (TAA 0.270 ± 0.02 iiM/ml/min) (p"],"dc:identifier":["oai:pure.atira.dk:studenttheses/46ddba5f-c171-4491-8b1e-07c63468be9d","https://pure.northampton.ac.uk/en/studentTheses/46ddba5f-c171-4491-8b1e-07c63468be9d"],"dc:language":["eng"],"dc:publisher.institution":["University of Northampton"],"dc:relation.isreferencedby":["https://pure.northampton.ac.uk/en/studentTheses/46ddba5f-c171-4491-8b1e-07c63468be9d"],"dc:title":["Inter-individual variation in saliva antioxidant status in relation to periodontal disease"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["Student thesis"],"dc:type.qualificationname":["Doctoral Thesis"]},"updated_at":"2026-07-24T03:26:33Z"}