Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder affecting children. Children with ADHD may have difficulty with maintaining focus and appropriate activity levels as well as controlling compulsive behaviors. Currently, the diagnostic criteria for ADHD is subjective and leads to frequent misdiagnosis and the subsequent use of prescription amphetamines which may lead to long term developmental cognitive alterations. Previous literature has identified ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 (ST3GAL3) as a possible genetic component underlying ADHD. This study uses Loop Mediated Isothermal Amplification (LAMP) to amplify the wild type of the ST3GAL3 gene in two groups of participants: one displaying ADHD characteristics as defined by the Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist, and one that does not. The current study has two aims: (1) To replicate findings that show participants with ADHD test negative for ST3GAL3 and (2) To further investigate the influence of anxiety and depression, two highly comorbid disorders with ADHD.
","abstract_html":"<p>Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder affecting children. Children with ADHD may have difficulty with maintaining focus and appropriate activity levels as well as controlling compulsive behaviors. Currently, the diagnostic criteria for ADHD is subjective and leads to frequent misdiagnosis and the subsequent use of prescription amphetamines which may lead to long term developmental cognitive alterations. Previous literature has identified ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 (ST3GAL3) as a possible genetic component underlying ADHD. This study uses Loop Mediated Isothermal Amplification (LAMP) to amplify the wild type of the ST3GAL3 gene in two groups of participants: one displaying ADHD characteristics as defined by the Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist, and one that does not. The current study has two aims: (1) To replicate findings that show participants with ADHD test negative for ST3GAL3 and (2) To further investigate the influence of anxiety and depression, two highly comorbid disorders with ADHD.</p>","abstract_has_math":false,"creators":["Thomas, Nicole"],"institution":null,"degree_name":"Master of Science","degree_level":"Thesis","degree_discipline":"Psychological Science","degree_department":null,"school":null,"contributors":["Amber LaCrosse"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2023,"date_issued":"2023-04-01T07:00:00Z","date_published":"2023-04-01T07:00:00Z","updated_at":"2026-07-24T03:24:36Z","subjects":["Attention Deficit Hyperactivity Disorder","ST3GAL3","genetics","LAMP","misdiagnosis","anxiety","depression","Psychology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://commons.nmu.edu/theses/743","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Amber LaCrosse"]},{"key":"dc:creator","label":"Author","values":["Thomas, Nicole"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2028-04-05T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Psychological Science"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Attention Deficit Hyperactivity Disorder","ST3GAL3","genetics","LAMP","misdiagnosis","anxiety","depression","Psychology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://commons.nmu.edu/theses/743"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder affecting children. Children with ADHD may have difficulty with maintaining focus and appropriate activity levels as well as controlling compulsive behaviors. Currently, the diagnostic criteria for ADHD is subjective and leads to frequent misdiagnosis and the subsequent use of prescription amphetamines which may lead to long term developmental cognitive alterations. Previous literature has identified ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 (ST3GAL3) as a possible genetic component underlying ADHD. This study uses Loop Mediated Isothermal Amplification (LAMP) to amplify the wild type of the ST3GAL3 gene in two groups of participants: one displaying ADHD characteristics as defined by the Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist, and one that does not. The current study has two aims: (1) To replicate findings that show participants with ADHD test negative for ST3GAL3 and (2) To further investigate the influence of anxiety and depression, two highly comorbid disorders with ADHD.
"]},{"key":"dc:title","label":"Title","values":["Genetic Alterations Associated with Attention Deficit Hyperactivity Disorder"]}]}],"canonical_facts":{"dc:contributor":["Amber LaCrosse"],"dc:creator":["Thomas, Nicole"],"dc:date.available":["2028-04-05T07:00:00Z"],"dc:description.abstract":["Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder affecting children. Children with ADHD may have difficulty with maintaining focus and appropriate activity levels as well as controlling compulsive behaviors. Currently, the diagnostic criteria for ADHD is subjective and leads to frequent misdiagnosis and the subsequent use of prescription amphetamines which may lead to long term developmental cognitive alterations. Previous literature has identified ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 (ST3GAL3) as a possible genetic component underlying ADHD. This study uses Loop Mediated Isothermal Amplification (LAMP) to amplify the wild type of the ST3GAL3 gene in two groups of participants: one displaying ADHD characteristics as defined by the Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist, and one that does not. The current study has two aims: (1) To replicate findings that show participants with ADHD test negative for ST3GAL3 and (2) To further investigate the influence of anxiety and depression, two highly comorbid disorders with ADHD.
"],"dc:identifier":["https://commons.nmu.edu/theses/743"],"dc:subject":["Attention Deficit Hyperactivity Disorder","ST3GAL3","genetics","LAMP","misdiagnosis","anxiety","depression","Psychology"],"dc:title":["Genetic Alterations Associated with Attention Deficit Hyperactivity Disorder"],"thesis:degree_discipline":["Psychological Science"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science"]},"updated_at":"2026-07-24T03:24:36Z"}