Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application

The purpose of this study is to determine the potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable polymers used are poly(L-lactic acid) (PLLA), and poly(lactide-co-glycolide) (PLGA). Two types of HA-polymer solutions are first prepared to achieve HA weight percentage of 0, 10, and 25%of the total combined weight of HA and PLLA, and HA and PLGA. The solutions are electrospun to form nanofibrous mats incorporated with HA powder. A biomimetic process was also conducted as a secondary approach. The nanofibrous mats obtained follow characterization using scanning electron microscope (SEM) - Energy Dispersive X-ray Analysis (EDXA), Thermogravimetric Analysis (TGA), and X-ray Diffraction (XRD). In this study, hydroxyapatite (HA) particles were successfully incorporated into the three dimensional porous biodegradable PLLA and PLGA polymer fiber mats by electrospinning.

Name thesis:degree_name

Master of Science in Biomedical Engineering - (M.S.)

Discipline thesis:degree_discipline

Biomedical Engineering

Year

2006

Author dc:creator

• Suzuki, Satomi

Contributors dc:contributor

• Treena Livingston Arinzeh
• Michael Jaffe
• George Collins

• Bone tissue engineering
• Electrospinning
• Biodegradable polymers
• Biomedical Engineering and Bioengineering

Repository record dc:identifier

https://digitalcommons.njit.edu/theses/450

OAI identifier oai:identifier

oai:digitalcommons.njit.edu:theses-1449