{"id":{"repo_id":"njit","oai_identifier":"oai:digitalcommons.njit.edu:theses-1359"},"canonical_url":"https://search.dev.ndltd.org/etd/njit/oai:digitalcommons.njit.edu:theses-1359","repository":{"repo_id":"njit","name":"NJIT","base_url":"https://digitalcommons.njit.edu/do/oai/"},"display":{"title":"Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions","abstract":"Stem cells have become increasingly important in the biomedical field because they have the potential to invade and regenerate damaged tissue. In particular, the bone marrow contains meesenchymal stem cells (MSCs) that have the capacity to differentiate into many cell lineages. The incorporation of MSCs within a multidimensional biomaterial provides a delivery vehicle to areas of injury. Natural and synthetic biomaterials can be made into scaffolds to represent different types of tissues. The ratio of synthetic to natural biomaterials in the scaffold influences the interaction with MSCs. This thesis created two different nanofibrous scaffolds by a process of electrospinning. The scaffolds consisted of a nanofiber mesh mimicking the extracellular matrix. One is derived solely from Poly-L-lactide acid and the other from Poly-L-lactide/Gelatin (50:50). Before and after culturing, measurements of fiber diameter, thermodynamics, and tensile strength were collected. Studies with primary human MSCs were conducted to characterize the in vitro behavior of MSCs seeded on and adhered to scaffolds of different compositions.","abstract_html":"Stem cells have become increasingly important in the biomedical field because they have the potential to invade and regenerate damaged tissue. In particular, the bone marrow contains meesenchymal stem cells (MSCs) that have the capacity to differentiate into many cell lineages. The incorporation of MSCs within a multidimensional biomaterial provides a delivery vehicle to areas of injury. Natural and synthetic biomaterials can be made into scaffolds to represent different types of tissues. The ratio of synthetic to natural biomaterials in the scaffold influences the interaction with MSCs. This thesis created two different nanofibrous scaffolds by a process of electrospinning. The scaffolds consisted of a nanofiber mesh mimicking the extracellular matrix. One is derived solely from Poly-L-lactide acid and the other from Poly-L-lactide/Gelatin (50:50). Before and after culturing, measurements of fiber diameter, thermodynamics, and tensile strength were collected. Studies with primary human MSCs were conducted to characterize the in vitro behavior of MSCs seeded on and adhered to scaffolds of different compositions.","abstract_has_math":false,"creators":["Moore, Lisamarie"],"institution":null,"degree_name":"Master of Science in Biomedical Engineering - (M.S.)","degree_level":null,"degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Pranela Rameshwar","Michael Jaffe","Treena Livingston Arinzeh"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-05-31T07:00:00Z","date_published":"2008-05-31T07:00:00Z","updated_at":"2026-07-24T03:23:16Z","subjects":["Mesenchymal stem cells","nanofibrous scaffolds","Biomedical Engineering and Bioengineering"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.njit.edu/theses/360","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pranela Rameshwar","Michael Jaffe","Treena Livingston Arinzeh"]},{"key":"dc:creator","label":"Author","values":["Moore, Lisamarie"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Biomedical Engineering - (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mesenchymal stem cells","nanofibrous scaffolds","Biomedical Engineering and Bioengineering"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.njit.edu/theses/360"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Stem cells have become increasingly important in the biomedical field because they have the potential to invade and regenerate damaged tissue. In particular, the bone marrow contains meesenchymal stem cells (MSCs) that have the capacity to differentiate into many cell lineages. The incorporation of MSCs within a multidimensional biomaterial provides a delivery vehicle to areas of injury. Natural and synthetic biomaterials can be made into scaffolds to represent different types of tissues. The ratio of synthetic to natural biomaterials in the scaffold influences the interaction with MSCs. This thesis created two different nanofibrous scaffolds by a process of electrospinning. The scaffolds consisted of a nanofiber mesh mimicking the extracellular matrix. One is derived solely from Poly-L-lactide acid and the other from Poly-L-lactide/Gelatin (50:50). Before and after culturing, measurements of fiber diameter, thermodynamics, and tensile strength were collected. Studies with primary human MSCs were conducted to characterize the in vitro behavior of MSCs seeded on and adhered to scaffolds of different compositions."]},{"key":"dc:title","label":"Title","values":["Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions"]}]}],"canonical_facts":{"dc:contributor":["Pranela Rameshwar","Michael Jaffe","Treena Livingston Arinzeh"],"dc:creator":["Moore, Lisamarie"],"dc:description.abstract":["Stem cells have become increasingly important in the biomedical field because they have the potential to invade and regenerate damaged tissue. In particular, the bone marrow contains meesenchymal stem cells (MSCs) that have the capacity to differentiate into many cell lineages. The incorporation of MSCs within a multidimensional biomaterial provides a delivery vehicle to areas of injury. Natural and synthetic biomaterials can be made into scaffolds to represent different types of tissues. The ratio of synthetic to natural biomaterials in the scaffold influences the interaction with MSCs. This thesis created two different nanofibrous scaffolds by a process of electrospinning. The scaffolds consisted of a nanofiber mesh mimicking the extracellular matrix. One is derived solely from Poly-L-lactide acid and the other from Poly-L-lactide/Gelatin (50:50). Before and after culturing, measurements of fiber diameter, thermodynamics, and tensile strength were collected. Studies with primary human MSCs were conducted to characterize the in vitro behavior of MSCs seeded on and adhered to scaffolds of different compositions."],"dc:identifier":["https://digitalcommons.njit.edu/theses/360"],"dc:subject":["Mesenchymal stem cells","nanofibrous scaffolds","Biomedical Engineering and Bioengineering"],"dc:title":["Interactions between adult human mesenchymal stem cells and nanofibrous scaffolds of different compositions"],"dc:type":["Thesis"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_name":["Master of Science in Biomedical Engineering - (M.S.)"]},"updated_at":"2026-07-24T03:23:16Z"}