{"id":{"repo_id":"njit","oai_identifier":"oai:digitalcommons.njit.edu:theses-1328"},"canonical_url":"https://search.dev.ndltd.org/etd/njit/oai:digitalcommons.njit.edu:theses-1328","repository":{"repo_id":"njit","name":"NJIT","base_url":"https://digitalcommons.njit.edu/do/oai/"},"display":{"title":"Brain segmentation using endogenous contrast mechanism using breath holding fMRI signal for tissue characterization","abstract":"MRL has fast become the modality of choice for the analysis of the complexity of the human brain. MRJ is a non-invasive method and gives high spatial resolution maps of the brain with soft tissue contrast. Conventional MRI technique modified to be used to image the functionality at high temporal resolution is known as fMRI. In fMRI the BOLD signal we measure is the hemodynamic response to neuronal and vascular changes at rest or in response to a stimulus where the various tissue types will have a different response. While fMRI has been traditionally been used to detect and identify eloquent regions of the cortex corresponding to specific tasks/stimulus, a number of groups have also used tMRI to study cerebrovascular changes and its consequence on the BOLD signal. A number of different perturbation methods including breath holding, hypercapnia, inhalation of various gas mixtures, and injection of acetozolamyde has been used to study spatio-temporal changes in the fMRI signal intensity. Spatiotemporal changes corresponding to changes in cerebral blood flow (CBF), cerebral blood volume (CBV), oxygen extraction fraction (OEF), and other physiological factors are then estimated and differences between diseased regions and healthy regions are then elucidated.","abstract_html":"MRL has fast become the modality of choice for the analysis of the complexity of the human brain. MRJ is a non-invasive method and gives high spatial resolution maps of the brain with soft tissue contrast. Conventional MRI technique modified to be used to image the functionality at high temporal resolution is known as fMRI. In fMRI the BOLD signal we measure is the hemodynamic response to neuronal and vascular changes at rest or in response to a stimulus where the various tissue types will have a different response. While fMRI has been traditionally been used to detect and identify eloquent regions of the cortex corresponding to specific tasks/stimulus, a number of groups have also used tMRI to study cerebrovascular changes and its consequence on the BOLD signal. A number of different perturbation methods including breath holding, hypercapnia, inhalation of various gas mixtures, and injection of acetozolamyde has been used to study spatio-temporal changes in the fMRI signal intensity. Spatiotemporal changes corresponding to changes in cerebral blood flow (CBF), cerebral blood volume (CBV), oxygen extraction fraction (OEF), and other physiological factors are then estimated and differences between diseased regions and healthy regions are then elucidated.","abstract_has_math":false,"creators":["Kakkad, Samata Mukesh"],"institution":null,"degree_name":"Master of Science in Biomedical Engineering - (M.S.)","degree_level":null,"degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Sergei Adamovich","Tara L. Alvarez","Bharat Biswal"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008-01-27T08:00:00Z","date_published":"2008-01-27T08:00:00Z","updated_at":"2026-07-24T03:23:16Z","subjects":["Cerebrovascular changes","fMRI","Cerebral blood flow","Cerebral blood volume","Oxygen extraction fraction","Biomedical Engineering and Bioengineering"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.njit.edu/theses/329","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Sergei Adamovich","Tara L. 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MRJ is a non-invasive method and gives high spatial resolution maps of the brain with soft tissue contrast. Conventional MRI technique modified to be used to image the functionality at high temporal resolution is known as fMRI. In fMRI the BOLD signal we measure is the hemodynamic response to neuronal and vascular changes at rest or in response to a stimulus where the various tissue types will have a different response. While fMRI has been traditionally been used to detect and identify eloquent regions of the cortex corresponding to specific tasks/stimulus, a number of groups have also used tMRI to study cerebrovascular changes and its consequence on the BOLD signal. A number of different perturbation methods including breath holding, hypercapnia, inhalation of various gas mixtures, and injection of acetozolamyde has been used to study spatio-temporal changes in the fMRI signal intensity. Spatiotemporal changes corresponding to changes in cerebral blood flow (CBF), cerebral blood volume (CBV), oxygen extraction fraction (OEF), and other physiological factors are then estimated and differences between diseased regions and healthy regions are then elucidated."]},{"key":"dc:title","label":"Title","values":["Brain segmentation using endogenous contrast mechanism using breath holding fMRI signal for tissue characterization"]}]}],"canonical_facts":{"dc:contributor":["Sergei Adamovich","Tara L. Alvarez","Bharat Biswal"],"dc:creator":["Kakkad, Samata Mukesh"],"dc:description.abstract":["MRL has fast become the modality of choice for the analysis of the complexity of the human brain. MRJ is a non-invasive method and gives high spatial resolution maps of the brain with soft tissue contrast. Conventional MRI technique modified to be used to image the functionality at high temporal resolution is known as fMRI. In fMRI the BOLD signal we measure is the hemodynamic response to neuronal and vascular changes at rest or in response to a stimulus where the various tissue types will have a different response. While fMRI has been traditionally been used to detect and identify eloquent regions of the cortex corresponding to specific tasks/stimulus, a number of groups have also used tMRI to study cerebrovascular changes and its consequence on the BOLD signal. A number of different perturbation methods including breath holding, hypercapnia, inhalation of various gas mixtures, and injection of acetozolamyde has been used to study spatio-temporal changes in the fMRI signal intensity. Spatiotemporal changes corresponding to changes in cerebral blood flow (CBF), cerebral blood volume (CBV), oxygen extraction fraction (OEF), and other physiological factors are then estimated and differences between diseased regions and healthy regions are then elucidated."],"dc:identifier":["https://digitalcommons.njit.edu/theses/329"],"dc:subject":["Cerebrovascular changes","fMRI","Cerebral blood flow","Cerebral blood volume","Oxygen extraction fraction","Biomedical Engineering and Bioengineering"],"dc:title":["Brain segmentation using endogenous contrast mechanism using breath holding fMRI signal for tissue characterization"],"dc:type":["Thesis"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_name":["Master of Science in Biomedical Engineering - (M.S.)"]},"updated_at":"2026-07-24T03:23:16Z"}