{"id":{"repo_id":"njit","oai_identifier":"oai:digitalcommons.njit.edu:theses-1307"},"canonical_url":"https://search.dev.ndltd.org/etd/njit/oai:digitalcommons.njit.edu:theses-1307","repository":{"repo_id":"njit","name":"NJIT","base_url":"https://digitalcommons.njit.edu/do/oai/"},"display":{"title":"An in vitro study to characterize a new automated high throughput neuronal stretch injury system","abstract":"Traumatic brain injury (TBI) is one of the most prevalent long-term neurological conditions and its overall economic consequences rival that of stroke. Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University of Pennsylvania, NJIT constructed a fully automated version, which injures neuronal cell cultures in uniaxial regime and provides the high experimental yield required in pharmaceutical and neuroscience studies. In this investigation, a new methodology for culturing primary cortical neurons of rat origin was established. Viable cell cultures developed for the first time in NJIT laboratory were successfully injured using the new NJIT device. The data recorded here may allow us to understand better the complex aspects of head trauma mechanisms and to develop potential therapeutic agents.","abstract_html":"Traumatic brain injury (TBI) is one of the most prevalent long-term neurological conditions and its overall economic consequences rival that of stroke. Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University of Pennsylvania, NJIT constructed a fully automated version, which injures neuronal cell cultures in uniaxial regime and provides the high experimental yield required in pharmaceutical and neuroscience studies. In this investigation, a new methodology for culturing primary cortical neurons of rat origin was established. Viable cell cultures developed for the first time in NJIT laboratory were successfully injured using the new NJIT device. The data recorded here may allow us to understand better the complex aspects of head trauma mechanisms and to develop potential therapeutic agents.","abstract_has_math":false,"creators":["Hususan, Nicolae Valerian"],"institution":null,"degree_name":"Master of Science in Biomedical Engineering - (M.S.)","degree_level":null,"degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Bryan J. Pfister","Richard A. Foulds","Max Roman"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-05-31T07:00:00Z","date_published":"2009-05-31T07:00:00Z","updated_at":"2026-07-24T03:23:16Z","subjects":["Traumatic brain injury","Primary cortical neuron culturing","Biomedical Engineering and Bioengineering"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.njit.edu/theses/308","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Bryan J. Pfister","Richard A. 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Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University of Pennsylvania, NJIT constructed a fully automated version, which injures neuronal cell cultures in uniaxial regime and provides the high experimental yield required in pharmaceutical and neuroscience studies. In this investigation, a new methodology for culturing primary cortical neurons of rat origin was established. Viable cell cultures developed for the first time in NJIT laboratory were successfully injured using the new NJIT device. The data recorded here may allow us to understand better the complex aspects of head trauma mechanisms and to develop potential therapeutic agents."]},{"key":"dc:title","label":"Title","values":["An in vitro study to characterize a new automated high throughput neuronal stretch injury system"]}]}],"canonical_facts":{"dc:contributor":["Bryan J. Pfister","Richard A. Foulds","Max Roman"],"dc:creator":["Hususan, Nicolae Valerian"],"dc:description.abstract":["Traumatic brain injury (TBI) is one of the most prevalent long-term neurological conditions and its overall economic consequences rival that of stroke. Considering the importance of the topic, new models for studying TBI are often designed and created. Based on a model developed by the University of Pennsylvania, NJIT constructed a fully automated version, which injures neuronal cell cultures in uniaxial regime and provides the high experimental yield required in pharmaceutical and neuroscience studies. In this investigation, a new methodology for culturing primary cortical neurons of rat origin was established. Viable cell cultures developed for the first time in NJIT laboratory were successfully injured using the new NJIT device. The data recorded here may allow us to understand better the complex aspects of head trauma mechanisms and to develop potential therapeutic agents."],"dc:identifier":["https://digitalcommons.njit.edu/theses/308"],"dc:subject":["Traumatic brain injury","Primary cortical neuron culturing","Biomedical Engineering and Bioengineering"],"dc:title":["An in vitro study to characterize a new automated high throughput neuronal stretch injury system"],"dc:type":["Thesis"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_name":["Master of Science in Biomedical Engineering - (M.S.)"]},"updated_at":"2026-07-24T03:23:16Z"}