Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion

Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although HME is traditionally utilizing synthetic polymers to produce such dosages, biopolymers constantly gain ground by virtue of renewability, biocompatibility and in some cases biodegradability. In this work, the possibility of using Keltone, a marine polysaccharide derived from brown seaweed, as a polymeric excipient for pharmaceutical HME is explored. Keltone is insoluble in acidic pH and soluble in basic pH, therefore making it suitable for intestinal drug release. The processability of Keltone by extrusion using water and Eudragit EPO as plasticizers, and Diphenhydramine Hydrochloride and Clotrimazoleas as active pharmaceutical ingredients is assessed. The amount of residual water in the extrudates is determined by thermogravimetric analysis. The thermal transitions of the extrudates are determined by Differential Scanning Calorimetry.

Name thesis:degree_name

Master of Science in Pharmaceutical Engineering - (M.S.)

Discipline thesis:degree_discipline

Chemical, Biological and Pharmaceutical Engineering

Year

2014

Author dc:creator

• Ye, Qing

Contributors dc:contributor

• Costas G. Gogos
• Piero M. Armenante
• Robert Benedict Barat

• Pharmaceutical hot melt extrusion (HME)
• Biopolymers
• Keltone
• Marine polysaccharide
• Brown seaweed
• Chemical Engineering
• Pharmaceutics and Drug Design

Repository record dc:identifier

https://digitalcommons.njit.edu/theses/204

OAI identifier oai:identifier

oai:digitalcommons.njit.edu:theses-1203