{"id":{"repo_id":"njit","oai_identifier":"oai:digitalcommons.njit.edu:theses-1125"},"canonical_url":"https://search.dev.ndltd.org/etd/njit/oai:digitalcommons.njit.edu:theses-1125","repository":{"repo_id":"njit","name":"NJIT","base_url":"https://digitalcommons.njit.edu/do/oai/"},"display":{"title":"The functional effects of barium and hypoxia on the in vitro respiratory activity","abstract":"The hypoxic respiratory response in mammals consists of a transit increase in the respiratory frequency (augmentation phase) followed by a decrease in frequency (depression phase). To understand how the central respiratory system contributes to this response, the in vitro transverse brainstem slice model is used, which contains the pre-Botzinger Complex, which is responsible for respiratory rhythm generation. The in vitro experiments performed for this thesis provide evidence that external barium exposure alters respiratory activity and significantly increases (P<0.00 1) the voltage of tonic activity under control oxygen conditions (95% FO2). During severe hypoxia (0% FO2), respiratory tonic activity is significantly elevatedduring the depression phase (from 0.55 to 0.95, n=6, P<0.001) by external barium, presumablydue to the closing of K+ channels and a reduction in K+ conductance.","abstract_html":"The hypoxic respiratory response in mammals consists of a transit increase in the respiratory frequency (augmentation phase) followed by a decrease in frequency (depression phase). To understand how the central respiratory system contributes to this response, the in vitro transverse brainstem slice model is used, which contains the pre-Botzinger Complex, which is responsible for respiratory rhythm generation. The in vitro experiments performed for this thesis provide evidence that external barium exposure alters respiratory activity and significantly increases (P&lt;0.00 1) the voltage of tonic activity under control oxygen conditions (95% FO2). During severe hypoxia (0% FO2), respiratory tonic activity is significantly elevatedduring the depression phase (from 0.55 to 0.95, n=6, P&lt;0.001) by external barium, presumablydue to the closing of K+ channels and a reduction in K+ conductance.","abstract_has_math":false,"creators":["Xu, Gaofeng"],"institution":null,"degree_name":"Master of Science in Biology - (M.S.)","degree_level":null,"degree_discipline":"Federated Department of Biological Sciences","degree_department":null,"school":null,"contributors":["Andrew Hill","Jorge P. Golowasch","Robert A. O'Brien"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-05-31T07:00:00Z","date_published":"2012-05-31T07:00:00Z","updated_at":"2026-07-24T03:22:26Z","subjects":["In vitro respiration","Hypoxic respiratory response","Biology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.njit.edu/theses/126","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Andrew Hill","Jorge P. Golowasch","Robert A. O'Brien"]},{"key":"dc:creator","label":"Author","values":["Xu, Gaofeng"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Federated Department of Biological Sciences"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Biology - (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["In vitro respiration","Hypoxic respiratory response","Biology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.njit.edu/theses/126"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The hypoxic respiratory response in mammals consists of a transit increase in the respiratory frequency (augmentation phase) followed by a decrease in frequency (depression phase). To understand how the central respiratory system contributes to this response, the in vitro transverse brainstem slice model is used, which contains the pre-Botzinger Complex, which is responsible for respiratory rhythm generation. The in vitro experiments performed for this thesis provide evidence that external barium exposure alters respiratory activity and significantly increases (P<0.00 1) the voltage of tonic activity under control oxygen conditions (95% FO2). During severe hypoxia (0% FO2), respiratory tonic activity is significantly elevatedduring the depression phase (from 0.55 to 0.95, n=6, P<0.001) by external barium, presumablydue to the closing of K+ channels and a reduction in K+ conductance."]},{"key":"dc:title","label":"Title","values":["The functional effects of barium and hypoxia on the in vitro respiratory activity"]}]}],"canonical_facts":{"dc:contributor":["Andrew Hill","Jorge P. Golowasch","Robert A. O'Brien"],"dc:creator":["Xu, Gaofeng"],"dc:description.abstract":["The hypoxic respiratory response in mammals consists of a transit increase in the respiratory frequency (augmentation phase) followed by a decrease in frequency (depression phase). To understand how the central respiratory system contributes to this response, the in vitro transverse brainstem slice model is used, which contains the pre-Botzinger Complex, which is responsible for respiratory rhythm generation. The in vitro experiments performed for this thesis provide evidence that external barium exposure alters respiratory activity and significantly increases (P<0.00 1) the voltage of tonic activity under control oxygen conditions (95% FO2). During severe hypoxia (0% FO2), respiratory tonic activity is significantly elevatedduring the depression phase (from 0.55 to 0.95, n=6, P<0.001) by external barium, presumablydue to the closing of K+ channels and a reduction in K+ conductance."],"dc:identifier":["https://digitalcommons.njit.edu/theses/126"],"dc:subject":["In vitro respiration","Hypoxic respiratory response","Biology"],"dc:title":["The functional effects of barium and hypoxia on the in vitro respiratory activity"],"dc:type":["Thesis"],"thesis:degree_discipline":["Federated Department of Biological Sciences"],"thesis:degree_name":["Master of Science in Biology - (M.S.)"]},"updated_at":"2026-07-24T03:22:26Z"}