{"id":{"repo_id":"njit","oai_identifier":"oai:digitalcommons.njit.edu:theses-1013"},"canonical_url":"https://search.dev.ndltd.org/etd/njit/oai:digitalcommons.njit.edu:theses-1013","repository":{"repo_id":"njit","name":"NJIT","base_url":"https://digitalcommons.njit.edu/do/oai/"},"display":{"title":"High performance lattice boltzmann method yield-stress calculations based on intravital images of clot formation in live mice","abstract":"Thrombo-embolic infarction is the major cause of mortality and morbidity in the United States, causing over 1 million strokes, heart attacks and other life-threatening thrombotic events each year in the United States. Conversely, deficiencies in these processes result in severe bleeding risks. The ability to access hydrodynamics stresses at which thrombus structure is likely to embolize can provide insight into the thrombogenesis process. Interestingly, the viscoelastic behavior exhibited by the thrombus resembles that of a Bingham fluid - a material that behaves as a rigid body at low stresses but flows as a viscous fluid when the stress exceeds critical yield stress. Hence, we decided to measure the critical yield stress at which the thrombi yield (and possibly emboli). The fluid-induced stresses are calculated via Lattice-Boltzmann fluid dynamic simulation based on in vivo microscopic images of laser injury-induced thrombi and simulation provided critical yield stress information. To our knowledge, this is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce risks of occlusion and embolism in patients.","abstract_html":"Thrombo-embolic infarction is the major cause of mortality and morbidity in the United States, causing over 1 million strokes, heart attacks and other life-threatening thrombotic events each year in the United States. Conversely, deficiencies in these processes result in severe bleeding risks. The ability to access hydrodynamics stresses at which thrombus structure is likely to embolize can provide insight into the thrombogenesis process. Interestingly, the viscoelastic behavior exhibited by the thrombus resembles that of a Bingham fluid - a material that behaves as a rigid body at low stresses but flows as a viscous fluid when the stress exceeds critical yield stress. Hence, we decided to measure the critical yield stress at which the thrombi yield (and possibly emboli). The fluid-induced stresses are calculated via Lattice-Boltzmann fluid dynamic simulation based on in vivo microscopic images of laser injury-induced thrombi and simulation provided critical yield stress information. To our knowledge, this is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce risks of occlusion and embolism in patients.","abstract_has_math":false,"creators":["Chandran, Vishnu Deep"],"institution":null,"degree_name":"Master of Science in Chemical Engineering - (M.S.)","degree_level":null,"degree_discipline":"Chemical, Biological and Pharmaceutical Engineering","degree_department":null,"school":null,"contributors":["Roman S. Voronov","S. Basuray","Max Roman"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-05-31T07:00:00Z","date_published":"2017-05-31T07:00:00Z","updated_at":"2026-07-24T03:22:01Z","subjects":["Thrombo-embolic infarction","Lattice-Boltzmann fluid dynamic simulation","Chemical Engineering"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.njit.edu/theses/14","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Roman S. Voronov","S. Basuray","Max Roman"]},{"key":"dc:creator","label":"Author","values":["Chandran, Vishnu Deep"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical, Biological and Pharmaceutical Engineering"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Chemical Engineering - (M.S.)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Thrombo-embolic infarction","Lattice-Boltzmann fluid dynamic simulation","Chemical Engineering"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.njit.edu/theses/14"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Thrombo-embolic infarction is the major cause of mortality and morbidity in the United States, causing over 1 million strokes, heart attacks and other life-threatening thrombotic events each year in the United States. Conversely, deficiencies in these processes result in severe bleeding risks. The ability to access hydrodynamics stresses at which thrombus structure is likely to embolize can provide insight into the thrombogenesis process. Interestingly, the viscoelastic behavior exhibited by the thrombus resembles that of a Bingham fluid - a material that behaves as a rigid body at low stresses but flows as a viscous fluid when the stress exceeds critical yield stress. Hence, we decided to measure the critical yield stress at which the thrombi yield (and possibly emboli). The fluid-induced stresses are calculated via Lattice-Boltzmann fluid dynamic simulation based on in vivo microscopic images of laser injury-induced thrombi and simulation provided critical yield stress information. To our knowledge, this is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce risks of occlusion and embolism in patients."]},{"key":"dc:title","label":"Title","values":["High performance lattice boltzmann method yield-stress calculations based on intravital images of clot formation in live mice"]}]}],"canonical_facts":{"dc:contributor":["Roman S. Voronov","S. Basuray","Max Roman"],"dc:creator":["Chandran, Vishnu Deep"],"dc:description.abstract":["Thrombo-embolic infarction is the major cause of mortality and morbidity in the United States, causing over 1 million strokes, heart attacks and other life-threatening thrombotic events each year in the United States. Conversely, deficiencies in these processes result in severe bleeding risks. The ability to access hydrodynamics stresses at which thrombus structure is likely to embolize can provide insight into the thrombogenesis process. Interestingly, the viscoelastic behavior exhibited by the thrombus resembles that of a Bingham fluid - a material that behaves as a rigid body at low stresses but flows as a viscous fluid when the stress exceeds critical yield stress. Hence, we decided to measure the critical yield stress at which the thrombi yield (and possibly emboli). The fluid-induced stresses are calculated via Lattice-Boltzmann fluid dynamic simulation based on in vivo microscopic images of laser injury-induced thrombi and simulation provided critical yield stress information. To our knowledge, this is the first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce risks of occlusion and embolism in patients."],"dc:identifier":["https://digitalcommons.njit.edu/theses/14"],"dc:subject":["Thrombo-embolic infarction","Lattice-Boltzmann fluid dynamic simulation","Chemical Engineering"],"dc:title":["High performance lattice boltzmann method yield-stress calculations based on intravital images of clot formation in live mice"],"dc:type":["Thesis"],"thesis:degree_discipline":["Chemical, Biological and Pharmaceutical Engineering"],"thesis:degree_name":["Master of Science in Chemical Engineering - (M.S.)"]},"updated_at":"2026-07-24T03:22:01Z"}