Synthesis and characterization of metal complexes 2-Benzoylpyridene and di-2-pyridyl ketone schiff base ligands derived from s-methyldithiocarbazate fragment and its application to biological activity toward P.Falciparum

The synthesis, characterization, spectroscopic and biological evaluation of 2-benzoylpyridine-s-methyldithiocarbazate (HL1) and di-2-pyradylketone-s-methyldithiocarbazate (HL2) with selected metal ions of copper (II), zinc (II), cadmium (II), nickel (II), iron (II) and cobalt (II). The ligands, HL1 and HL2 were synthesized by an acid catalyzed condensation reaction of s-methyldithiocarbazate with 2-benzoylpyradine and di-2-pyradylketone respectively. The reaction of metal salts with the resultant ligands, HL1 and HL2 produced solid complexes. The ligands and the complexes were characterized by means of Elemental Analysis (EA), Fourier Transform Infrared (FT-IR) spectroscopy, Nuclear Magnetic Resonance (1HNMR) spectroscopy. HL1 and HL2 ligands coordinated in their deprotonated form through one of the pyridine nitrogen atoms, the azomethine nitrogen atom and the thiolate sulfur atom, thus HL1 and HL2 behaved as tridentate N, N, S chelate with all coordinated respective metal ions centers. The synthesized ligands and their corresponding metal complexes were screened for anti-plasmodial activities against malaria parasite using in vitro technique. Using IC50 (half inhibitory concentration) to measure the biological strength of the compounds. It revealed that ligands were more biological active toward NF54 strain of P. falciparum than their corresponding metal complexes and that HL1 have increased antiplamodial activity than its counterpart HL2.

Grantor dc:publisher

University of Namibia

Year dc:date.issued

2015

Author dc:creator

• Uusiku, Alina

• Metal complexes
• Biological activity
• P. Falciparum
• 2-Benzoylpyridine
• Di-2-Pyridyl

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/11070/1689

OAI identifier oai:identifier

oai:repository.unam.edu.na:11070/1689