Synthesis and characterization of transition and some group 14 metal complexes containing ligands derived from 2-acetylpyridine and hydrazide derivatives, and their antiplasmodium activities
The synthesis and characterization of two sets of metal complexes containing ligands derived from 2-acetylpyridine and hydrazide derivatives is reported. The first set consists of complexes containing a ligand derived from 2-acetylpyridine and S-methyldithiocarbazate while the second set is of complexes containing a ligand derived from 2-acetypyridine and thiocarbohydrazide. The ligands were synthesized via an acid catalysed condensation reaction and the metal complexes were synthesized by direct mixing of the ligand dissolved in ethanol with a corresponding metal salt dissolved in water. The compounds were characterized by means of Elemental Analysis (EA), Infrared (IR) spectroscopy, Mass Spectroscopy (MS) and proton Nuclear Magnetic Resonance (1HNMR) spectroscopy. Metal complexes with formulas of PbL2, Ag(HL)NO3 and Sn(L)Cl were obtained from the S-methyldithiocarbazate containing ligand. The thiocarbohydrazone ligand gave bimetallic complexes of manganese(II) and zinc(II) with general formulas that can be represented as M2(HL)Cl3 (M = Mn or Zn, and HL is the deprotonated ligand) The ligands and their corresponding metal complexes were tested for antiplasmodial activity against a chloroquine sensitive strain (NF54), of the Plasmodium falciparum of the malaria parasite. The NF54:IC50 results show that the divalent metallic complexes of the thiocarbohydrazone possess better activity toward this strain better than the parent ligand. The complexes of the S-methyldithiocarbazate containing ligand show lower activity in comparison to their parent ligand.
Metal complexes, Ligands, Acetylpyridine, Hydrazide
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