Design and Development of Biocompatible MOFS and Silica-Based Nanocarriers with Controlled Pharmacokinetics for Drug Delivery Applications
"In the past decade, a big interest has drawn into nanoporous metal-organic frameworks (MOFs) and silica-based materials as nanocarriers for drug delivery applications, owing to their exceptionally high surface area and highly structured porous network. The overall goal of this research was to optimize the pharmacokinetic behavior of several highly porous biocompatible drug carriers that have the potential to carry Ibuprofen, 5-Fluorouracil, and Curcumin to the desired tissue without creating a burst effect and minimizing the amount of dosage and size that conventional capsules require. The specific objectives of this study are to (i) assess the effect of drug solubility on pharmacokinetics of Mg-MOF-74; (ii) Examine the effect of pore diameter and volume on drug release rate from MIL-101(Cr) and MIL-101(Cr)-pore expanded nanocarriers; and (iii) determine the effects of pore size and pore network topology on drug release rate from unimodal and bimodal silica-based materials such UMV-7 unimodal, UMV-7 bimodal, SBA-15, and commercial PD-09024. The bare materials and their drug-incorporated analogues were characterized N2 physisorption, X-ray diffraction (XRD) analysis, and Fourier Transform infrared (FTIR) analysis to confirm successful drug loading and to assess any changes to physiochemical properties upon drug loading. The drug release experiments were performed via HPLC analysis for a period of 24 h in phosphate buffered saline (PBS) medium as an analogue of human body fluid, and the Higuchi technique was used to model for quantification of drug release rates. The results revealed all carriers possessed high surface area and porosity which allowed successful impregnation of the drugs, and fast drug release kinetics"-- Abstract, p. iv
Missouri University of Science and Technology
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