\"Novel small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their in vitro inhibitory activities have been studied by 13C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and AGE-breakers were found to be more effective in their sequestration of AGE intermediates, such as dehydroascorbate (DHA) than the state-of-the art phenacylthiazolium bromide (PTB)-based AGE-inhibitors and AGE-breakers. Citric acid and other polyphenolic antioxidants have substantial AGE inhibitory effects in the D-glucose/leucine or benzylamine Maillard reaction model systems, and thus they are suitable as dietary additives for ameliorating AGE-induced complications.
Organofluorine compounds have found numerous applications as pharmaceutically interesting compounds, and toward developing novel synthetic methods for organofluorine compounds, we have investigated synthetic strategies for gem-difluoro and trifluormethyl compounds. gem-Difluorination of 1,3-dithiolanes, obtained from the corresponding ketones, form gem-difluoromethylene compounds through the photoredox catalysis, using photocatalyst 9-fluorenone in the presence of visible light (household bulb 13W CFL). This reaction proceeds under mild conditions and is applicable to gem-difluorination of variously substituted diaryl 1,3-dithiolanes. We have also developed a novel NHC-catalyzed trifluoromethylation of aromatic N-tosyl aldimines with electron-withdrawing as well as electron-donating groups on the aryl ring. We have synthesized a series of novel purine-based triazole derivatives as potential CDK-inhibitors and characterized their structures using high-field 1H- and 13C-NMR spectroscopy”--Abstract, page iii.
","abstract_html":"<p>"Novel small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their <em>in vitro</em> inhibitory activities have been studied by <sup>13</sup>C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and AGE-breakers were found to be more effective in their sequestration of AGE intermediates, such as dehydroascorbate (DHA) than the state-of-the art phenacylthiazolium bromide (PTB)-based AGE-inhibitors and AGE-breakers. Citric acid and other polyphenolic antioxidants have substantial AGE inhibitory effects in the D-glucose/leucine or benzylamine Maillard reaction model systems, and thus they are suitable as dietary additives for ameliorating AGE-induced complications.</p> <p>Organofluorine compounds have found numerous applications as pharmaceutically interesting compounds, and toward developing novel synthetic methods for organofluorine compounds, we have investigated synthetic strategies for <em>gem</em>-difluoro and trifluormethyl compounds. <em>gem</em>-Difluorination of 1,3-dithiolanes, obtained from the corresponding ketones, form <em>gem</em>-difluoromethylene compounds through the photoredox catalysis, using photocatalyst 9-fluorenone in the presence of visible light (household bulb 13W CFL). This reaction proceeds under mild conditions and is applicable to <em>gem</em>-difluorination of variously substituted diaryl 1,3-dithiolanes. We have also developed a novel NHC-catalyzed trifluoromethylation of aromatic N-tosyl aldimines with electron-withdrawing as well as electron-donating groups on the aryl ring. We have synthesized a series of novel purine-based triazole derivatives as potential CDK-inhibitors and characterized their structures using high-field <sup>1</sup>H- and <sup>13</sup>C-NMR spectroscopy”--Abstract, page iii.</p>","abstract_has_math":false,"creators":["Mehta, Jatin"],"institution":"Missouri University of Science and Technology","degree_name":"Ph. D. in Chemistry","degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-07-24T03:18:09Z","subjects":["Analytical Chemistry","Organic Chemistry"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarsmine.mst.edu/doctoral_dissertations/3136","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Mehta, Jatin"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["Dissertation - Open Access"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph. D. in Chemistry"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Missouri University of Science and Technology"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Analytical Chemistry","Organic Chemistry"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarsmine.mst.edu/doctoral_dissertations/3136"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["\"Novel small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their in vitro inhibitory activities have been studied by 13C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and AGE-breakers were found to be more effective in their sequestration of AGE intermediates, such as dehydroascorbate (DHA) than the state-of-the art phenacylthiazolium bromide (PTB)-based AGE-inhibitors and AGE-breakers. Citric acid and other polyphenolic antioxidants have substantial AGE inhibitory effects in the D-glucose/leucine or benzylamine Maillard reaction model systems, and thus they are suitable as dietary additives for ameliorating AGE-induced complications.
Organofluorine compounds have found numerous applications as pharmaceutically interesting compounds, and toward developing novel synthetic methods for organofluorine compounds, we have investigated synthetic strategies for gem-difluoro and trifluormethyl compounds. gem-Difluorination of 1,3-dithiolanes, obtained from the corresponding ketones, form gem-difluoromethylene compounds through the photoredox catalysis, using photocatalyst 9-fluorenone in the presence of visible light (household bulb 13W CFL). This reaction proceeds under mild conditions and is applicable to gem-difluorination of variously substituted diaryl 1,3-dithiolanes. We have also developed a novel NHC-catalyzed trifluoromethylation of aromatic N-tosyl aldimines with electron-withdrawing as well as electron-donating groups on the aryl ring. We have synthesized a series of novel purine-based triazole derivatives as potential CDK-inhibitors and characterized their structures using high-field 1H- and 13C-NMR spectroscopy”--Abstract, page iii.
"]},{"key":"dc:title","label":"Title","values":["Part I: Design, synthesis, and studies of novel age-inhibitors and age-breakers; Part II: Novel synthetic methods for organofluorine compound"]}]}],"canonical_facts":{"dc:creator":["Mehta, Jatin"],"dc:description.abstract":["\"Novel small molecule inhibitors and breakers of advanced glycation end-products (AGEs) have been synthesized and their in vitro inhibitory activities have been studied by 13C NMR, fluorescence, and UV-visible spectroscopy. We have demonstrated that these AGE-inhibitors and AGE-breakers were found to be more effective in their sequestration of AGE intermediates, such as dehydroascorbate (DHA) than the state-of-the art phenacylthiazolium bromide (PTB)-based AGE-inhibitors and AGE-breakers. Citric acid and other polyphenolic antioxidants have substantial AGE inhibitory effects in the D-glucose/leucine or benzylamine Maillard reaction model systems, and thus they are suitable as dietary additives for ameliorating AGE-induced complications.
Organofluorine compounds have found numerous applications as pharmaceutically interesting compounds, and toward developing novel synthetic methods for organofluorine compounds, we have investigated synthetic strategies for gem-difluoro and trifluormethyl compounds. gem-Difluorination of 1,3-dithiolanes, obtained from the corresponding ketones, form gem-difluoromethylene compounds through the photoredox catalysis, using photocatalyst 9-fluorenone in the presence of visible light (household bulb 13W CFL). This reaction proceeds under mild conditions and is applicable to gem-difluorination of variously substituted diaryl 1,3-dithiolanes. We have also developed a novel NHC-catalyzed trifluoromethylation of aromatic N-tosyl aldimines with electron-withdrawing as well as electron-donating groups on the aryl ring. We have synthesized a series of novel purine-based triazole derivatives as potential CDK-inhibitors and characterized their structures using high-field 1H- and 13C-NMR spectroscopy”--Abstract, page iii.
"],"dc:identifier":["https://scholarsmine.mst.edu/doctoral_dissertations/3136"],"dc:subject":["Analytical Chemistry","Organic Chemistry"],"dc:title":["Part I: Design, synthesis, and studies of novel age-inhibitors and age-breakers; Part II: Novel synthetic methods for organofluorine compound"],"dc:type":["Dissertation - Open Access"],"thesis:degree_name":["Ph. D. in Chemistry"],"thesis:institution_name":["Missouri University of Science and Technology"]},"updated_at":"2026-07-24T03:18:09Z"}