Randomized clinical study in split mouth: use of ozoral pro® and gel® compared with 1% chlorexidine gel in sites affected by peri-implant mucositis
Peri-implant mucositis consists of a reversible inflammation of peri-implant tissues characterized by bleeding on gentle probing in the absence of bone loss. Ozone therapy is being extensively studied for its efficacy in treating different dental conditions. To date, few studies have evaluated ozone as an adjunct to the oral hygiene measures of peri-implant mucositis patients. The aim of the present study is to assess the efficacy of an ozonized gel (Trial group) compared to chlorhexidine (Control group) after a domiciliary protocol of oral hygiene in a 24-month study. According to a split-mouth study design, patients were divided into Group 1 for the application of chlorhexidine gel in peri-implant mucositis sites of quadrants Q1 and Q4, whereas in quadrants Q2 and Q3, the ozonized gel was administered inoffice. For Group 2, the quadrants were reversed. At baseline (T0), and after 1 (T1), 2 (T2), and 3 (T3) months, At baseline (T0) and after one (T1), three (T2), six (T3), nine (T4 ), twelve (T5), fifteen (T6), eighteen (T7), twenty-one (T8), twenty-four (T9) months, the following indices of peri-implant mucositis were recorded: probing pocket depth (PPD), index plaque (PI), gingival bleeding index (GBI), bleeding score (BS), marginal mucosal condition (MMC). Both for the ozonized gel and for chlorhexidine there was a significant decrease in all the peri-implant mucositis indices studied. In contrast, no significant variations were found in intergroup comparisons. The greater improvements for BS, GBI and MMC inflammatory indices of the ozonized gel gel compared to chlorhexidine suggest the importance of further studies to investigate the relevance of the product itself. The ozonized gel deserves particular attention, considering the better outcome than chlorhexidine on specific clinical periodontal parameters, as well as its lesser shortcomings.
Ozone, Ozonated Oils, Peri-implant mucositis, Chlorhexidine, Scaling and Root Planing, Implants, Periodontal Parameteres, Randomized Clinical Traial, Experimental Surgery, Gases, Ozono, Aceites Ozonizados, Mucositis periimplantaria, Clorhexidina, Raspado y Alisado Radicular, Parámetros Periodontales, Ensayo clínico aleatorizado, Cirurgia Experimental
Universidad Catolica de Murcia - Doctoral
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