{"id":{"repo_id":"montana-tech","oai_identifier":"oai:scholarworks.umt.edu:etd-2093"},"canonical_url":"https://search.dev.ndltd.org/etd/montana-tech/oai:scholarworks.umt.edu:etd-2093","repository":{"repo_id":"montana-tech","name":"Montana Technology","base_url":"https://scholarworks.umt.edu/do/oai/"},"display":{"title":"The role of the CB1 receptor in learning, memory and anxiety-like behaviors","abstract":"Several lines of evidence support a role of the endocannabinoid (eCB) system in cognition and anxiety. This study explores cognitive processes and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal learning. In the Light-Dark Box and Suok tasks, the CB1-/- mice demonstrated greater anxiety-like behaviors relative the CB1+/+ mice. No differences were observed in the Open-Field task, suggesting that the observed behavioral differences may be related to anxiety rather than cognitive impairments. This study has important implications for neuropsychiatric disorders, including depression and post-traumatic stress disorder.","abstract_html":"Several lines of evidence support a role of the endocannabinoid (eCB) system in cognition and anxiety. This study explores cognitive processes and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal learning. In the Light-Dark Box and Suok tasks, the CB1-/- mice demonstrated greater anxiety-like behaviors relative the CB1+/+ mice. No differences were observed in the Open-Field task, suggesting that the observed behavioral differences may be related to anxiety rather than cognitive impairments. This study has important implications for neuropsychiatric disorders, including depression and post-traumatic stress disorder.","abstract_has_math":false,"creators":["Bolyard, Loretta Lynn"],"institution":"University of Montana","degree_name":"Doctor of Philosophy (PhD)","degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-01-01T08:00:00Z","date_published":"2009-01-01T08:00:00Z","updated_at":"2026-07-24T03:14:14Z","subjects":["age","anxiety","CB1 receptor","endocannabinoid","learning","memory"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://scholarworks.umt.edu/etd/1074","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Bolyard, Loretta Lynn"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:publisher","label":"Institution","values":["University of Montana"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["age","anxiety","CB1 receptor","endocannabinoid","learning","memory"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarworks.umt.edu/etd/1074"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Several lines of evidence support a role of the endocannabinoid (eCB) system in cognition and anxiety. This study explores cognitive processes and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal learning. In the Light-Dark Box and Suok tasks, the CB1-/- mice demonstrated greater anxiety-like behaviors relative the CB1+/+ mice. No differences were observed in the Open-Field task, suggesting that the observed behavioral differences may be related to anxiety rather than cognitive impairments. This study has important implications for neuropsychiatric disorders, including depression and post-traumatic stress disorder."]},{"key":"dc:title","label":"Title","values":["The role of the CB1 receptor in learning, memory and anxiety-like behaviors"]}]}],"canonical_facts":{"dc:creator":["Bolyard, Loretta Lynn"],"dc:description.abstract":["Several lines of evidence support a role of the endocannabinoid (eCB) system in cognition and anxiety. This study explores cognitive processes and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal learning. In the Light-Dark Box and Suok tasks, the CB1-/- mice demonstrated greater anxiety-like behaviors relative the CB1+/+ mice. No differences were observed in the Open-Field task, suggesting that the observed behavioral differences may be related to anxiety rather than cognitive impairments. This study has important implications for neuropsychiatric disorders, including depression and post-traumatic stress disorder."],"dc:identifier":["https://scholarworks.umt.edu/etd/1074"],"dc:publisher":["University of Montana"],"dc:subject":["age","anxiety","CB1 receptor","endocannabinoid","learning","memory"],"dc:title":["The role of the CB1 receptor in learning, memory and anxiety-like behaviors"],"dc:type":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T03:14:14Z"}