Diels-Alder Reactions of 5-[Methoxypoly(Oxyethylene)]-(3E)-1,3-Pentadiene

Poly(ethylene glycol) (PEG) derivatives have wide utility for a variety of biomedical and biotechnical applications, and interest continues in the synthesis of new PEG derivatives that possess novel properties. In this work, we have performed the synthesis of 5-[methoxypoly(oxyethylene)]-(3E)-1,3-pentadiene (Ia) and 5-methoxyethoxy-(3E)-1,3-pentadiene (Ib). Diels-Alder reactions of Ia and Ib with acrolein, maleic anhydride, and diethyl acetylenedicarboxylate have been performed. The products of these reactions have been analyzed by spectroscopic techniques. The Diels-Alder adducts of Ia with maleic anhydride and acrolein are converted corresponding N-hydroxysuccinamide esters. Hydrolysis of these esters have been studied, and their hydrolysis reactions have been investigated.

Name thesis:degree_name

Master of Science in Chemistry

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Chemistry and Biochemistry

Year

1999

Author dc:creator

• Hopkins, Timothy Edward

Contributors dc:contributor

• Reza Herati

• Chemistry

Statement dc:rights

• © Timothy Edward Hopkins

Repository record dc:identifier

https://bearworks.missouristate.edu/theses/348

OAI identifier oai:identifier

oai:bearworks.missouristate.edu:theses-1349