Murine Peritoneal Macrophage Response to Colonial Phenotypes of Candida Albicans
type: CreativeWork
description: The ability of Candida albicans to change from yeast to mycelial form has been associated with pathogenicity of the organism. High frequently switching is a phenomenon that occurs spontaneously and has been documented in clinical isolates from oral and vaginal candidiasis. Because switched phenotypes have a propensity to form hyphae more readily than the parent type, switching may enhance opportunistic capabilities for eluding or resisting macrophage surveillance. The focus of this investigation was to test murine peritoneal macrophage response to two different phenotypes of the same strain of C. albicans. Heat-killed preparations of the parent and a UV-induced, switched phenotype (S-5) were tested for their capacity to prime macrophages for enhanced respiratory burst and interleukin-1 (IL-1) secretion. The results of this investigation demonstrate that murine peritoneal macrophages respond to priming by the parent phenotype to a different degre than to the S-5 varian of C. albicans 3153A.
abstract: The ability of Candida albicans to change from yeast to mycelial form has been associated with pathogenicity of the organism. High frequently switching is a phenomenon that occurs spontaneously and has been documented in clinical isolates from oral and vaginal candidiasis. Because switched phenotypes have a propensity to form hyphae more readily than the parent type, switching may enhance opportunistic capabilities for eluding or resisting macrophage surveillance. The focus of this investigation was to test murine peritoneal macrophage response to two different phenotypes of the same strain of C. albicans. Heat-killed preparations of the parent and a UV-induced, switched phenotype (S-5) were tested for their capacity to prime macrophages for enhanced respiratory burst and interleukin-1 (IL-1) secretion. The results of this investigation demonstrate that murine peritoneal macrophages respond to priming by the parent phenotype to a different degre than to the S-5 varian of C. albicans 3153A.
author: Horton, Janice L.
keywords: Biology
date published: 1988-12-01T08:00:00Z
date modified: 2026-07-24T03:15:12Z
provider: Missouri State University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Missouri State University