{"id":{"repo_id":"mo-state","oai_identifier":"oai:bearworks.missouristate.edu:theses-1135"},"canonical_url":"https://search.dev.ndltd.org/etd/mo-state/oai:bearworks.missouristate.edu:theses-1135","repository":{"repo_id":"mo-state","name":"Missouri State University","base_url":"https://bearworks.missouristate.edu/do/oai/"},"display":{"title":"The Effect of Candida Hyphal Inhibitory Product (Chip) on Murine Peritoneal Macrophage Killing of Candida Albicans Hyphae","abstract":"Dimorphic conversion of Candida albicans from the yeast to the hyphal form plays a critical role in the pathogenicity of the fungus. Macrophages, phagocytic cells of the immune system, are able to recognize and kill both forms of the fungus through different mechanisms. Recent investigations have reported that C. albicans is capable of producing a natural inhibitor (CHIP) which decreases the efficiency by which PMNs phagocytize C. albicans yeast. The focus of this study was to determine the effect of candida hyphal inhibitory product (CHIP) upon contact-mediated killing of the hyphal form of C. albicans by Listeria monocytogenes activated macrophages. Results demonstrate that CHIP diminished macrophage contact-meditated killing of Candida hyphae.","abstract_html":"Dimorphic conversion of Candida albicans from the yeast to the hyphal form plays a critical role in the pathogenicity of the fungus. Macrophages, phagocytic cells of the immune system, are able to recognize and kill both forms of the fungus through different mechanisms. Recent investigations have reported that C. albicans is capable of producing a natural inhibitor (CHIP) which decreases the efficiency by which PMNs phagocytize C. albicans yeast. The focus of this study was to determine the effect of candida hyphal inhibitory product (CHIP) upon contact-mediated killing of the hyphal form of C. albicans by Listeria monocytogenes activated macrophages. Results demonstrate that CHIP diminished macrophage contact-meditated killing of Candida hyphae.","abstract_has_math":false,"creators":["Spence, Angela L."],"institution":null,"degree_name":"Master of Science in Biology","degree_level":"Masters","degree_discipline":"Biology","degree_department":null,"school":null,"contributors":["Richard Myers"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1993,"date_issued":"1993-07-01T07:00:00Z","date_published":"1993-07-01T07:00:00Z","updated_at":"2026-07-24T03:15:12Z","subjects":["Biology"],"languages":[],"rights":["© Angela L Spence"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://bearworks.missouristate.edu/theses/134","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Richard Myers"]},{"key":"dc:creator","label":"Author","values":["Spence, Angela L."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science in Biology"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["© Angela L Spence"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://bearworks.missouristate.edu/theses/134"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Dimorphic conversion of Candida albicans from the yeast to the hyphal form plays a critical role in the pathogenicity of the fungus. Macrophages, phagocytic cells of the immune system, are able to recognize and kill both forms of the fungus through different mechanisms. Recent investigations have reported that C. albicans is capable of producing a natural inhibitor (CHIP) which decreases the efficiency by which PMNs phagocytize C. albicans yeast. The focus of this study was to determine the effect of candida hyphal inhibitory product (CHIP) upon contact-mediated killing of the hyphal form of C. albicans by Listeria monocytogenes activated macrophages. Results demonstrate that CHIP diminished macrophage contact-meditated killing of Candida hyphae."]},{"key":"dc:title","label":"Title","values":["The Effect of Candida Hyphal Inhibitory Product (Chip) on Murine Peritoneal Macrophage Killing of Candida Albicans Hyphae"]}]}],"canonical_facts":{"dc:contributor":["Richard Myers"],"dc:creator":["Spence, Angela L."],"dc:description.abstract":["Dimorphic conversion of Candida albicans from the yeast to the hyphal form plays a critical role in the pathogenicity of the fungus. Macrophages, phagocytic cells of the immune system, are able to recognize and kill both forms of the fungus through different mechanisms. Recent investigations have reported that C. albicans is capable of producing a natural inhibitor (CHIP) which decreases the efficiency by which PMNs phagocytize C. albicans yeast. The focus of this study was to determine the effect of candida hyphal inhibitory product (CHIP) upon contact-mediated killing of the hyphal form of C. albicans by Listeria monocytogenes activated macrophages. Results demonstrate that CHIP diminished macrophage contact-meditated killing of Candida hyphae."],"dc:identifier":["https://bearworks.missouristate.edu/theses/134"],"dc:rights":["© Angela L Spence"],"dc:subject":["Biology"],"dc:title":["The Effect of Candida Hyphal Inhibitory Product (Chip) on Murine Peritoneal Macrophage Killing of Candida Albicans Hyphae"],"thesis:degree_discipline":["Biology"],"thesis:degree_level":["Masters"],"thesis:degree_name":["Master of Science in Biology"]},"updated_at":"2026-07-24T03:15:12Z"}