Analysis of NusA's roles in DNA repair and damage tolerance pathways in Escherichia coli

NusA has long known to be a bona fide transcription factor that functions in both termination and antitermination. However, its role in DNA repair and damage tolerance has not been explored until recently. Cohen et al. proposed for the first time that NusA functions as a coupling factor in transcription-coupled translesion synthesis (TC-TLS) and nucleotide excision repair (TCR) processes. A very recent paper by Nudler's lab further supports Cohen's NusA-dependent TCR model. The objectives of the work described here are to gain a deeper understanding of the precise mechanism NusA uses to facilitate DNA repair and damage tolerance.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2015

Author dc:creator

• Zhao, Yimin, S.M. Massachusetts Institute of Technology

Advisor dc:contributor.advisor

• Graham C. Walker.

• Biology.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/98635

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/98635