Optical domain subsampling for data-efficient optical coherence tomography (OCT)

Recent advances in optical coherence tomography (OCT) have led to higher-speed sources that support imaging over longer depth ranges. Limitations in the bandwidth of state-of-the-art acquisition electronics, however, prevent adoption of these advances into clinical applications. This thesis introduces optical-domain subsampling as a method for increasing the imaging range while reducing the acquisition bandwidth. Optically subsampled lasers utilize a discrete set of wavelengths to alias fringe signals along an extended depth range into a bandwidth limited window. By detecting the complex fringe signals and under the assumption of a depth-constrained signal, optical domain subsampling enables recovery of the depth-resolved scattering signal without overlapping artifacts. Key principles behind subsampled imaging will be discussed, as well as the design criteria for an experimental subsampled laser. A description of the laser, interferometer, data acquisition system, and signal processing steps is given, and the results of point spread functions compressed into a baseband window are presented. Images that were taken with the subsampled OCT system and a wide-field microscope show that this imaging scheme is viable in vivo and can advantageously image samples that span a long depth range.

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2013

Author dc:creator

• Siddiqui, Meena

Advisor dc:contributor.advisor

• Benjamin J. Vakoc.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/82390

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/82390