{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/78158"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/78158","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"From bench to bedside : impact of conflict-of-interest restrictions at academic medical centers on clinical trials","abstract":"Successful translation of scientific discovery into new medicines is most successful with collaboration between academics - scientists and physicians - and industry. In recent years, there has been increasing concern at academic medical centers about the impact of relationships with industry on patient care and student education. This has generally resulted in more stringent conflict-of-interest rules. This paper seeks to better understand the impact of these conflict-of-interest rules. In the first part, it explores research to-date on the importance of relationships between industry and academia and discusses some of the concerns that have arisen. In the second part, this relationship is better characterized with clinical trial data. The findings suggest that there is a strong trend towards schools with higher conflict-of-interest rules having fewer clinical trials. This suggests that although there may be benefits to stricter regulation, there are trade-offs in terms of clinical translation.","abstract_html":"Successful translation of scientific discovery into new medicines is most successful with collaboration between academics - scientists and physicians - and industry. In recent years, there has been increasing concern at academic medical centers about the impact of relationships with industry on patient care and student education. This has generally resulted in more stringent conflict-of-interest rules. This paper seeks to better understand the impact of these conflict-of-interest rules. In the first part, it explores research to-date on the importance of relationships between industry and academia and discusses some of the concerns that have arisen. In the second part, this relationship is better characterized with clinical trial data. The findings suggest that there is a strong trend towards schools with higher conflict-of-interest rules having fewer clinical trials. This suggests that although there may be benefits to stricter regulation, there are trade-offs in terms of clinical translation.","abstract_has_math":false,"creators":["Campbell, Elyssa Sarah"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Harvard--MIT Program in Health Sciences and Technology.","school":null,"contributors":[],"advisors":["Fiona Murray and Anthony Sinskey."],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-22T22:21:37Z","subjects":["Harvard--MIT Program in Health Sciences and Technology."],"languages":["eng"],"rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1721.1/78158","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Fiona Murray and Anthony Sinskey."]},{"key":"dc:contributor.department","label":"Department","values":["Harvard--MIT Program in Health Sciences and Technology."]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Harvard--MIT Program in Health Sciences and Technology."]},{"key":"dc:creator","label":"Author","values":["Campbell, Elyssa Sarah"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2013-03-28T18:09:20Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2013-03-28T18:09:20Z"]},{"key":"dc:date.issued","label":"Date","values":["2012"]},{"key":"dc:publisher","label":"Institution","values":["Massachusetts Institute of Technology"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Harvard--MIT Program in Health Sciences and Technology."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["M.I.T. theses are protected by copyright. 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In recent years, there has been increasing concern at academic medical centers about the impact of relationships with industry on patient care and student education. This has generally resulted in more stringent conflict-of-interest rules. This paper seeks to better understand the impact of these conflict-of-interest rules. In the first part, it explores research to-date on the importance of relationships between industry and academia and discusses some of the concerns that have arisen. In the second part, this relationship is better characterized with clinical trial data. The findings suggest that there is a strong trend towards schools with higher conflict-of-interest rules having fewer clinical trials. This suggests that although there may be benefits to stricter regulation, there are trade-offs in terms of clinical translation."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["S.M.in Health Sciences and Technology"]},{"key":"dc:title","label":"Title","values":["From bench to bedside : impact of conflict-of-interest restrictions at academic medical centers on clinical trials"]}]}],"canonical_facts":{"dc:contributor.advisor":["Fiona Murray and Anthony Sinskey."],"dc:contributor.department":["Harvard--MIT Program in Health Sciences and Technology."],"dc:contributor.other":["Harvard--MIT Program in Health Sciences and Technology."],"dc:creator":["Campbell, Elyssa Sarah"],"dc:date.accessioned":["2013-03-28T18:09:20Z"],"dc:date.available":["2013-03-28T18:09:20Z"],"dc:date.issued":["2012"],"dc:description":["Thesis (S.M. in Health Sciences and Technology)--Harvard-MIT Program in Health Sciences and Technology, 2012.","\"September 2012.\" Cataloged from PDF version of thesis.","Includes bibliographical references (p. 37-40)."],"dc:description.abstract":["Successful translation of scientific discovery into new medicines is most successful with collaboration between academics - scientists and physicians - and industry. In recent years, there has been increasing concern at academic medical centers about the impact of relationships with industry on patient care and student education. This has generally resulted in more stringent conflict-of-interest rules. This paper seeks to better understand the impact of these conflict-of-interest rules. In the first part, it explores research to-date on the importance of relationships between industry and academia and discusses some of the concerns that have arisen. In the second part, this relationship is better characterized with clinical trial data. The findings suggest that there is a strong trend towards schools with higher conflict-of-interest rules having fewer clinical trials. This suggests that although there may be benefits to stricter regulation, there are trade-offs in terms of clinical translation."],"dc:description.degree":["S.M.in Health Sciences and Technology"],"dc:identifier.uri":["http://hdl.handle.net/1721.1/78158"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Harvard--MIT Program in Health Sciences and Technology."],"dc:title":["From bench to bedside : impact of conflict-of-interest restrictions at academic medical centers on clinical trials"],"dc:type":["Thesis"]},"updated_at":"2026-07-22T22:21:37Z"}