Design of a rapid, continuous, small-scale device for creating dry powders from concentrated suspensions containing active pharmaceutical ingredients

Current methods of producing pharmaceutical compounds are large batch processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient could be reduced to less than ten days. The scope of this paper encompasses the design of a machine for the desiccation of a mixture of solvent and pharmaceutical compound. The goal of this project was to provide a small-scale, high throughput method of continuous pharmaceutical drug drying for Novartis-MIT Center for Continuous Manufacturing. Specifications included a product flow rate of 100 grams per hour and a final product form of flowable powder. Several machines were built and tested, with the final design being comprised of a convective drum dryer and a modular continuous vacuum dryer.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2011

Author dc:creator

• Correll, Eric Owen

Advisor dc:contributor.advisor

• Alexander H. Slocum.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/68832

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/68832