Design and validation of chronic research tools for an implantable closed-loop neurostimulator

Neurostimulators today provide high frequency Deep Brain Stimulation (DBS) for therapeutic modulation of diseased neural circuits. These devices are approved for the treatment of Parkinson's Disease, Essential Tremor and Dystonia, and are in clinical evaluations for Epilepsy and Depression. Despite the success of DBS therapy, the current systems are open-loop, where the clinician is the sensor and control algorithm, and hence these are programmed with stimulation parameter settings based on acute clinical observations. The need to move towards an effective closed-loop system drives the research for understanding the dynamics of the neural circuits. This work assessed the feasibility of use of a unique implantable research tool, which has sensing and algorithm technology added to an existing DBS device, for a chronic, in-vivo study of the brain state dynamics in an ovine model and presented preliminary validation of the neural interface. In addition, the sensing technology of this bi-directional neural interface was also validated using data from Brain Machine Interface studies. Finally, the work also involved development of a software tool which is a platform for analyzing neural activity datasets from different studies using machine learning techniques.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2011

Author dc:creator

• Shafquat, Afsah

Advisor dc:contributor.advisor

• Timothy A. Dension and Steven B. Leeb.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/66809

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/66809