{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/59930"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/59930","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Experimental technique for optimizing aerosolized vaccine efficacy by Erika J. Sandford.","abstract":"Vaccination via aerosol has been proven to be as safe, as effective, and more appropriate for transportation when compared with vaccination via injection. These advantages make aerosolized vaccinations a realistic alternative to traditional injection vaccines for the developing world, where cold chain systems are impractical and the use of hypodermic needles can be unsafe. However, more research is needed to determine optimal parameters for vaccine aerosolization. This thesis presents an experimental setup to test Aerovax, a device designed to deliver aerosolized vaccinations in developing regions of the world. The experimental technique is the first effort to optimize vaccine aerosols across multiple variables, including input pressure, nebulizer geometry, and vaccine reconstitution. The setup provides a pressure input, sensors for ambient properties, and a device to measure particle size distribution.","abstract_html":"Vaccination via aerosol has been proven to be as safe, as effective, and more appropriate for transportation when compared with vaccination via injection. These advantages make aerosolized vaccinations a realistic alternative to traditional injection vaccines for the developing world, where cold chain systems are impractical and the use of hypodermic needles can be unsafe. However, more research is needed to determine optimal parameters for vaccine aerosolization. This thesis presents an experimental setup to test Aerovax, a device designed to deliver aerosolized vaccinations in developing regions of the world. The experimental technique is the first effort to optimize vaccine aerosols across multiple variables, including input pressure, nebulizer geometry, and vaccine reconstitution. The setup provides a pressure input, sensors for ambient properties, and a device to measure particle size distribution.","abstract_has_math":false,"creators":["Sandford, Erika J. (Erika Jaye)"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Dept. of Mechanical Engineering.","school":null,"contributors":[],"advisors":["Sanjay Sarma."],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-22T22:22:21Z","subjects":["Mechanical Engineering."],"languages":["eng"],"rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1721.1/59930","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Sanjay Sarma."]},{"key":"dc:contributor.department","label":"Department","values":["Massachusetts Institute of Technology. Dept. of Mechanical Engineering."]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Massachusetts Institute of Technology. Dept. of Mechanical Engineering."]},{"key":"dc:creator","label":"Author","values":["Sandford, Erika J. (Erika Jaye)"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-11-08T17:47:57Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-11-08T17:47:57Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher","label":"Institution","values":["Massachusetts Institute of Technology"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mechanical Engineering."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1721.1/59930"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.","Cataloged from PDF version of thesis.","Includes bibliographical references (p. 26)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Vaccination via aerosol has been proven to be as safe, as effective, and more appropriate for transportation when compared with vaccination via injection. These advantages make aerosolized vaccinations a realistic alternative to traditional injection vaccines for the developing world, where cold chain systems are impractical and the use of hypodermic needles can be unsafe. However, more research is needed to determine optimal parameters for vaccine aerosolization. This thesis presents an experimental setup to test Aerovax, a device designed to deliver aerosolized vaccinations in developing regions of the world. The experimental technique is the first effort to optimize vaccine aerosols across multiple variables, including input pressure, nebulizer geometry, and vaccine reconstitution. The setup provides a pressure input, sensors for ambient properties, and a device to measure particle size distribution."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["S.B."]},{"key":"dc:title","label":"Title","values":["Experimental technique for optimizing aerosolized vaccine efficacy by Erika J. Sandford."]}]}],"canonical_facts":{"dc:contributor.advisor":["Sanjay Sarma."],"dc:contributor.department":["Massachusetts Institute of Technology. Dept. of Mechanical Engineering."],"dc:contributor.other":["Massachusetts Institute of Technology. Dept. of Mechanical Engineering."],"dc:creator":["Sandford, Erika J. (Erika Jaye)"],"dc:date.accessioned":["2010-11-08T17:47:57Z"],"dc:date.available":["2010-11-08T17:47:57Z"],"dc:date.issued":["2010"],"dc:description":["Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.","Cataloged from PDF version of thesis.","Includes bibliographical references (p. 26)."],"dc:description.abstract":["Vaccination via aerosol has been proven to be as safe, as effective, and more appropriate for transportation when compared with vaccination via injection. These advantages make aerosolized vaccinations a realistic alternative to traditional injection vaccines for the developing world, where cold chain systems are impractical and the use of hypodermic needles can be unsafe. However, more research is needed to determine optimal parameters for vaccine aerosolization. This thesis presents an experimental setup to test Aerovax, a device designed to deliver aerosolized vaccinations in developing regions of the world. The experimental technique is the first effort to optimize vaccine aerosols across multiple variables, including input pressure, nebulizer geometry, and vaccine reconstitution. The setup provides a pressure input, sensors for ambient properties, and a device to measure particle size distribution."],"dc:description.degree":["S.B."],"dc:identifier.uri":["http://hdl.handle.net/1721.1/59930"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Mechanical Engineering."],"dc:title":["Experimental technique for optimizing aerosolized vaccine efficacy by Erika J. Sandford."],"dc:type":["Thesis"]},"updated_at":"2026-07-22T22:22:21Z"}