Drug delivery device for bladder disorders

Several pathologies associated with the bladder have wide impacts on society. Overactive bladder (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS) are chronic urological conditions characterized by pain, urinary frequency, and urgency with or without urinary incontinence. The estimated prevalence of OAB and IC/PBS is more than 34 million people in the U.S. alone. The American Cancer Society estimated a total of 68,810 new bladder cancer cases and 14,100 deaths from bladder cancer in the U.S. in 2008. Treatment options include oral medications, transdermal patches and intravesical instillations of therapeutic solutions. Direct intravesical instillation is considered an effective option, especially for those who remain refractory to oral and transdermal formulations due to intolerable side effects and skin irritations, respectively. Intravesical treatment, however, requires repeated instillations due to rapid drug voiding by urination, and the frequent urinary catheterizations involve risk of urinary infection and patient discomfort. An alternative, site-specific local delivery approach was created using a reservoir-based drug delivery device. This novel passive device was designed to release drug in a predetermined manner once inside the bladder. The device also possesses a retention feature to prevent accidental voiding. The device can be implanted into and retrieved from the bladder by a non-surgical cystoscopic procedure.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2009

Author dc:creator

• Lee, Heejin, 1976-

Advisor dc:contributor.advisor

• Michael J. Cima.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/58169

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/58169